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Four new dinuclear Cu(II) hydrazone complexes using various organic spacers: syntheses, crystal structures, DNA binding and cleavage studies and selective cell inhibitory effect towards leukemic and normal lymphocytes.

hal.structure.identifierDepartment of Chemistry
dc.contributor.authorBANERJEE, Sambuddha
hal.structure.identifierInfectious Diseases & Immunology Division
dc.contributor.authorMONDAL, Susmita
hal.structure.identifierDepartment of Chemistry
dc.contributor.authorSEN, Soma
hal.structure.identifierDepartment of Chemistry
dc.contributor.authorDAS, Saurabh
hal.structure.identifierSchool of Chemical Sciences and Pharmacy
dc.contributor.authorHUGHES, David L.
hal.structure.identifierDipartimento di Chimica [GIAF]
dc.contributor.authorRIZZOLI, Corrado
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDESPLANCHES, Cédric
hal.structure.identifierInfectious Diseases & Immunology Division
dc.contributor.authorMANDAL, Chitra
hal.structure.identifierDepartment of Chemistry
dc.contributor.authorMITRA, Samiran
dc.date.issued2009
dc.identifier.issn1477-9226
dc.description.abstractEnSyntheses and crystal structures of four new hydrazone-based Cu(II) complexes, [{Cu(L1)(H2O)}2(-pyraz)](ClO4)2 (1), [{Cu(L1)(OClO3)}2(-4,4-bipy)] (2), [{Cu(L2H)}(-pyraz){Cu(L2H)(OClO3)}].(ClO4) (3) and [{Cu(L2)}2(-bpe)] (4) [L1H = condensation product of benzhydrazide and pyridine-2-carbaldehyde and L2H2 = condensation product of benzoyl acetone and benzhydrazide], bridged by various organic spacers [pyrazine (pyraz), 4,4-bipyridine (4,4-bipy) and 1,2-di(4-pyridyl)ethane (bpe)] are reported in this paper. The single-crystal X-ray crystallographic studies reveal that all are dinuclear units where 1 and 3 form strong intermolecular H-bonding to form sheets of interconnected ions, whereas 2 forms sheets of dinuclear chains through – interactions; in 4, molecules are linked only through van der Waals interactions. The variable-temperature magnetic moment studies reveal that 1 and 3 show antiferromagnetic coupling between the Cu(II) centers at lower temperatures. The binding ability of 1 with calf thymus DNA [CT-DNA] is reported using various spectroscopic studies (UV-Vis titration, circular dichroism and fluorescence). The binding constants of 1 with CT-DNA, as calculated by different methodologies, are of the order of 105 M−1. The mode of interaction between 1 and CT-DNA has been predicted using circular dichroic (CD) spectroscopy, where it has been shown that 1 most probably interacts with DNA via intercalation between the base pairs leading to a change in B-DNA conformation. 1 is also able to cleave supercoiled (SC) plasmid DNA pUC19 in a time and dose dependent manner as demonstrated by agarose gel electrophoresis, and also demonstrates its potential to cleave the SC plasmid DNA via both oxidative and hydrolytic mechanisms. Approximately 50% of leukemic cells are found to be dead when two representative leukemic cell lines are exposed to 1 (80 M) even for 24 h as determined by different cell cytotoxicity assays. Preliminary results also showed that, at 20 M, 1 could selectively induce apoptosis in leukemic cells without affecting normal lymphocytes.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title.enFour new dinuclear Cu(II) hydrazone complexes using various organic spacers: syntheses, crystal structures, DNA binding and cleavage studies and selective cell inhibitory effect towards leukemic and normal lymphocytes.
dc.typeArticle de revue
dc.identifier.doi10.1039/b903072g
dc.subject.halChimie/Matériaux
bordeaux.journalDalton Transactions
bordeaux.page6849-6860
bordeaux.issue34
bordeaux.peerReviewedoui
hal.identifierhal-00423823
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00423823v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Dalton%20Transactions&rft.date=2009&rft.issue=34&rft.spage=6849-6860&rft.epage=6849-6860&rft.eissn=1477-9226&rft.issn=1477-9226&rft.au=BANERJEE,%20Sambuddha&MONDAL,%20Susmita&SEN,%20Soma&DAS,%20Saurabh&HUGHES,%20David%20L.&rft.genre=article


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