Production of magnetic multilamellar liposomes as highly T(2)-efficient MRI contrast agents.
| hal.structure.identifier | Centre de recherches Paul Pascal [CRPP] | |
| dc.contributor.author | MEYRE, Marie-Edith | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | RAFFARD, Gérard | |
| hal.structure.identifier | Centre de résonance magnétique des systèmes biologiques [CRMSB] | |
| dc.contributor.author | FRANCONI, Jean-Michel | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | DUGUET, Etienne | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | LAMBERT, Olivier | |
| hal.structure.identifier | Chimie et Biologie des Membranes et des Nanoobjets [CBMN] | |
| dc.contributor.author | FAURE, Chrystel | |
| dc.date.issued | 2011 | |
| dc.identifier.issn | 1743-5889 | |
| dc.description.abstractEn | Lipid-based multilamellar vesicles loaded with aminosilane-modified maghemite nanoparticles (a-MNPs), also called magnetonions (MO), were analyzed for their magnetic resonance imaging (MRI) contrast agent properties. They were shown to be better T(2)-MRI contrast agents than commercial contrast agents and other reported liposome-based contrast agents as shown by their higher value of relaxivity ratio (r(2)/r(1) = 17), although a lower magnetic field intensity was used (0.2 T). Their high efficiency was explained by the aggregation of a-MNPs in between multilamellar vesicles, bilayers induced by MO preparation, and evidenced by cryo-TEM imaging. Magnetonions are then a promising platform for diagnosis and therapy. FROM THE CLINICAL EDITOR: In this study, magnetonions (MO) are presented as a very potent T2 relaxation enhancing MRI contrast agents. Such agents may be used in cell labeling and molecular imaging applications. | |
| dc.language.iso | en | |
| dc.publisher | Future Medicine | |
| dc.title.en | Production of magnetic multilamellar liposomes as highly T(2)-efficient MRI contrast agents. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.nano.2010.10.011 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Nanomedicine | |
| bordeaux.page | 18-21 | |
| bordeaux.volume | 7 | |
| bordeaux.issue | 1 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00565258 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00565258v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Nanomedicine&rft.date=2011&rft.volume=7&rft.issue=1&rft.spage=18-21&rft.epage=18-21&rft.eissn=1743-5889&rft.issn=1743-5889&rft.au=MEYRE,%20Marie-Edith&RAFFARD,%20G%C3%A9rard&FRANCONI,%20Jean-Michel&DUGUET,%20Etienne&LAMBERT,%20Olivier&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||