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hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierImagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB]
dc.contributor.authorLAMBERT, Olivier
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierImagerie Moléculaire et Nanobiotechnologies - Institut Européen de Chimie et Biologie [IECB]
dc.contributor.authorBRISSON, Alain
dc.date.issued2005
dc.identifier.issn1530-6984
dc.description.abstractEnThe controlled fabrication of biocompatible devices made of lipid bilayers deposited onto flat solid supports presents interest as models of cell membranes as well as for their biotechnological applications. We report here on the formation of supported lipid bilayers on silica nanoparticles (nanoSLBs). The successive steps of the adsorption of lipid vesicles on nanoparticles and the formation of nanoSLBs are revealed in detail by cryotransmission electron microscopy (cryo-EM). The formation of nanoSLBs was achieved for liposomes with positive, neutral, and low net negative charge, while liposomes with a high net negative charge adsorbed to silica nanoparticles but did not rupture. The nanoSLBs were found to follow faithfully the surface contours of the particles, information yet unavailable for SLB formation on planar solid substrates.
dc.language.isoen
dc.publisherAmerican Chemical Society
dc.subject.enAtomic-force microscopy
dc.subject.enPhospholipid-bilayers
dc.subject.enPhysical properties
dc.subject.enVesicle adsorption
dc.subject.enMembranes
dc.subject.enSurfaces
dc.subject.enLiposomes
dc.subject.enSpheres
dc.subject.enKinetics
dc.subject.enAdhesion
dc.title.enThe formation of supported lipid bilayers on silica nanoparticles revealed by cryoelectron microscopy
dc.typeArticle de revue
dc.identifier.doi10.1021/nl048153y
dc.subject.halChimie/Matériaux
bordeaux.journalNano Letters
bordeaux.page281-285
bordeaux.volume5
bordeaux.issue2
bordeaux.peerReviewedoui
hal.identifierhal-00022099
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00022099v1
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