Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents.
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| hal.structure.identifier | Department of Chemistry [CICECO] | |
| hal.structure.identifier | Departments of Physics [CICECO] | |
| dc.contributor.author | PINHO, Sonia L. C. | |
| hal.structure.identifier | Department of Life Sciences | |
| dc.contributor.author | FANECA, Henrique | |
| hal.structure.identifier | Department of Life Sciences | |
| dc.contributor.author | GERALDES, Carlos F. G. C. | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | DELVILLE, Marie-Hélène | |
| hal.structure.identifier | Departments of Physics [CICECO] | |
| dc.contributor.author | CARLOS, Luís D. | |
| hal.structure.identifier | Department of Chemistry [CICECO] | |
| dc.contributor.author | ROCHA, João | |
| dc.date.issued | 2012 | |
| dc.identifier.issn | 0142-9612 | |
| dc.description.abstractEn | The design and synthesis of a combined MRI-optical probe for bio-imaging are reported. The materials studied join the properties of lanthanide (Ln(3+)) complexes and nanoparticles (NPs), offering an excellent solution for bimodal imaging. The hybrid SiO(2)@APS/DTPA:Gd:Ln (Ln = Eu(3+) or Tb(3+)) (APS: 3-aminopropyltriethoxysilane, DTPA: diethylenetriamine pentaacetic acid) system increases the payload of the active magnetic centre (Gd(3+)) and introduces a Ln(3+) long-life excited state (Eu(3+): 0.35 ± 0.02 ms, Tb(3+): 1.87 ± 0.02 ms), with resistance to photobleaching and sharp emission bands. The Eu(3+) ions reside in a single low-symmetry site. Although the photoluminescence emission is not influenced by the simultaneous presence of Gd(3+) and Eu(3+), a moderate r(1) increase and a larger enhancement of r(2) are observed, particularly at high fields, due to susceptibility effects on r(2). The presence of Tb(3+) instead of Eu(3+) further raises r(1) but decreases r(2). These values are constant over a wide (5-13) pH range, indicating the paramagnetic NPs stability and absence of leaching. The uptake of NPs by living cells is fast and results in an intensity increase in the T(1)-weighted MRI images. The optical properties of the NPs in cellular pellets are also studied, confirming their potential as bimodal imaging agents. | |
| dc.language.iso | en | |
| dc.publisher | Elsevier | |
| dc.title.en | Lanthanide-DTPA grafted silica nanoparticles as bimodal-imaging contrast agents. | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1016/j.biomaterials.2011.09.086 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | Biomaterials | |
| bordeaux.page | 925-935 | |
| bordeaux.volume | 33 | |
| bordeaux.issue | 3 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00649661 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| dc.subject.it | Nanoparticle | |
| dc.subject.it | Bimodal imaging | |
| dc.subject.it | MRI contrast agents | |
| dc.subject.it | Optical contrast agents | |
| dc.subject.it | Photoluminescence | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00649661v1 | |
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