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Silica nanoparticles for bimodal MRI-optical imaging by grafting Gd3+ and Eu3+/Tb3+ complexes
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| hal.structure.identifier | Department of Chemistry [CICECO] | |
| dc.contributor.author | PINHO, Sonia Luzia Claro | |
| hal.structure.identifier | Department of Life Sciences | |
| dc.contributor.author | FANECA, Henrique | |
| hal.structure.identifier | Department of Life Sciences | |
| dc.contributor.author | GERALDES, Carlos F. G. C. | |
| hal.structure.identifier | Department of Chemistry [CICECO] | |
| dc.contributor.author | ROCHA, João | |
| hal.structure.identifier | Department of Chemistry [CICECO] | |
| dc.contributor.author | CARLOS, Luis D. | |
| hal.structure.identifier | Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB] | |
| dc.contributor.author | DELVILLE, Marie-Hélène | |
| dc.date.issued | 2012 | |
| dc.identifier.issn | 1434-1948 | |
| dc.description.abstractEn | Bimodal magnetic resonance imaging (MRI)/optical probes for bioimaging were obtained by grafting two types of lanthanide metal ions, Gd3+ and Eu3+/Tb3+, on the surface of SiO2 nanoparticles. The resulting systems were endowed with relaxometry and photoluminescent properties, respectively. Grafting a pyridine-based aromatic backbone on to the silica surface enhances the emission quantum yield of the Eu3+-containing nanoparticles fivefold compared to similar systems that bear no aromatic antennae. The emission properties of the mixed Ln3+/Gd3+-based nanoparticles are not influenced by the presence of Gd3+. The relaxometric properties of these samples are slightly better than the properties of commercial [Gd(DTPA)]2 (DTPA = diethylenetriaminepentaacetate). When taken up by RAW 264.7 cells (mouse macrophage cell line), such bimodal probes exhibit both T1-weighted MRI increased contrast and fluorescence tracking. | |
| dc.language.iso | en | |
| dc.publisher | Wiley-VCH Verlag | |
| dc.title.en | Silica nanoparticles for bimodal MRI-optical imaging by grafting Gd3+ and Eu3+/Tb3+ complexes | |
| dc.type | Article de revue | |
| dc.identifier.doi | 10.1002/ejic.201101110 | |
| dc.subject.hal | Chimie/Matériaux | |
| bordeaux.journal | European Journal of Inorganic Chemistry | |
| bordeaux.page | 2828-2837 | |
| bordeaux.issue | 16 | |
| bordeaux.peerReviewed | oui | |
| hal.identifier | hal-00700862 | |
| hal.version | 1 | |
| hal.popular | non | |
| hal.audience | Internationale | |
| dc.subject.it | Nanoparticles | |
| dc.subject.it | Imaging agents | |
| dc.subject.it | Luminescence | |
| dc.subject.it | Bimodal imaging | |
| dc.subject.it | MRI contrast agents | |
| hal.origin.link | https://hal.archives-ouvertes.fr//hal-00700862v1 | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Inorganic%20Chemistry&rft.date=2012&rft.issue=16&rft.spage=2828-2837&rft.epage=2828-2837&rft.eissn=1434-1948&rft.issn=1434-1948&rft.au=PINHO,%20Sonia%20Luzia%20Claro&FANECA,%20Henrique&GERALDES,%20Carlos%20F.%20G.%20C.&ROCHA,%20Jo%C3%A3o&CARLOS,%20Luis%20D.&rft.genre=article |
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