PINHO, Sonia Luzia Claro; FANECA, Henrique; GERALDES, Carlos F. G. C.; ROCHA, João; CARLOS, Luis D.; DELVILLE, Marie-Hélène

doi:10.1002/ejic.201101110

Métadonnées

Licence d’utilisation du document

PINHO, Sonia Luzia Claro
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
Department of Chemistry [CICECO]

FANECA, Henrique
Department of Life Sciences

GERALDES, Carlos F. G. C.
Department of Life Sciences

Langue

Article de revue

Ce document a été publié dans

European Journal of Inorganic Chemistry. 2012 n° 16, p. 2828-2837

Wiley-VCH Verlag

Résumé en anglais

Bimodal magnetic resonance imaging (MRI)/optical probes for bioimaging were obtained by grafting two types of lanthanide metal ions, Gd3+ and Eu3+/Tb3+, on the surface of SiO2 nanoparticles. The resulting systems were endowed with relaxometry and photoluminescent properties, respectively. Grafting a pyridine-based aromatic backbone on to the silica surface enhances the emission quantum yield of the Eu3+-containing nanoparticles fivefold compared to similar systems that bear no aromatic antennae. The emission properties of the mixed Ln3+/Gd3+-based nanoparticles are not influenced by the presence of Gd3+. The relaxometric properties of these samples are slightly better than the properties of commercial [Gd(DTPA)]2 (DTPA = diethylenetriaminepentaacetate). When taken up by RAW 264.7 cells (mouse macrophage cell line), such bimodal probes exhibit both T1-weighted MRI increased contrast and fluorescence tracking.< Réduire

Mots clés en italien

Nanoparticles

Imaging agents

Luminescence

Bimodal imaging

MRI contrast agents

Métadonnées

Licence d’utilisation du document

Silica nanoparticles for bimodal MRI-optical imaging by grafting Gd3+ and Eu3+/Tb3+ complexes

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en italien

DOI

Origine

Unités de recherche