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Poly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release.

hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLIU, Ji
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorDETREMBLEUR, Christophe
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorDEBUIGNE, Antoine
hal.structure.identifierLaboratory of Mammalian Cell Culture [GIGA-R]
dc.contributor.authorDE PAUW-GILLET, Marie-Claire
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorMORNET, Stéphane
hal.structure.identifierNMR Laboratory, Université de Mons
dc.contributor.authorVANDER ELST, Luce
hal.structure.identifierNMR Laboratory, Université de Mons
dc.contributor.authorLAURENT, Sophie
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorLABRUGÈRE, Christine
hal.structure.identifierInstitut de Chimie de la Matière Condensée de Bordeaux [ICMCB]
dc.contributor.authorDUGUET, Etienne
hal.structure.identifierCentre d'Etude et de Recherche sur les Macromolécules [CERM]
dc.contributor.authorJÉRÔME, Christine
dc.date.issued2013
dc.identifier.issn2040-3364
dc.description.abstractEnOriginal core/corona nanoparticles composed of a maghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment.
dc.language.isoen
dc.publisherRoyal Society of Chemistry
dc.title.enPoly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release.
dc.typeArticle de revue
dc.identifier.doi10.1039/c3nr02861e
dc.subject.halChimie/Matériaux
bordeaux.journalNanoscale
bordeaux.page11464-11477
bordeaux.volume5
bordeaux.issue23
bordeaux.peerReviewedoui
hal.identifierhal-00921276
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00921276v1
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