LIU, Ji; DETREMBLEUR, Christophe; DEBUIGNE, Antoine; DE PAUW-GILLET, Marie-Claire; MORNET, Stéphane; VANDER ELST, Luce; LAURENT, Sophie; LABRUGÈRE, Christine; DUGUET, Etienne; JÉRÔME, Christine

doi:10.1039/c3nr02861e

Métadonnées

Licence d’utilisation du document

LIU, Ji
Centre d'Etude et de Recherche sur les Macromolécules [CERM]
Institut de Chimie de la Matière Condensée de Bordeaux [ICMCB]

DETREMBLEUR, Christophe
Centre d'Etude et de Recherche sur les Macromolécules [CERM]

DEBUIGNE, Antoine
Centre d'Etude et de Recherche sur les Macromolécules [CERM]

Langue

Article de revue

Ce document a été publié dans

Nanoscale. 2013, vol. 5, n° 23, p. 11464-11477

Royal Society of Chemistry

Résumé en anglais

Original core/corona nanoparticles composed of a maghemite core and a stimuli-responsive polymer coating made of poly(acrylic acid)-block-poly(vinyl alcohol) macromolecules were fabricated for drug delivery system (DDS) application. This kind of DDS aims to combine the advantage of stimuli-responsive polymer coating, in order to regulate the drug release behaviours under different conditions and furthermore, improve the biocompatibility and in vivo circulation half-time of the maghemite nanoparticles. Drug loading capacity was evaluated with methylene blue (MB), a cationic model drug. The triggered release of MB was studied under various stimuli such as pH, ionic strength and temperature. Local heating generated under alternating magnetic field (AMF) application was studied, and remotely AMF-triggered release was also confirmed, while a mild heating-up of the release medium was observed. Furthermore, their potential application as magnetic resonance imaging (MRI) contrast agents was explored via relaxivity measurements and acquisition of T2-weighted images. Preliminary studies on the cytotoxicity against mouse fibroblast-like L929 cell line and also their cellular uptake within human melanoma MEL-5 cell line were carried out. In conclusion, this kind of stimuli-responsive nanoparticles appears to be promising carriers for delivering drugs to some tumour sites or into cellular compartments with an acidic environment.< Réduire

Métadonnées

Licence d’utilisation du document

Poly(acrylic acid)-block-poly(vinyl alcohol) anchored maghemite nanoparticles designed for multi-stimuli triggered drug release.

Langue

Ce document a été publié dans

Résumé en anglais

DOI

Origine

Unités de recherche