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Incidence of cytomegalovirus infection in seropositive kidney transplant recipients treated with everolimus: A randomized, open-label, multicenter phase 4 trial

dc.rights.licenseopenen_US
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorKAMINSKI, Hannah
dc.contributor.authorKAMAR, Nassim
dc.contributor.authorTHAUNAT, Olivier
dc.contributor.authorBOUVIER, Nicolas
dc.contributor.authorCAILLARD, Sophie
dc.contributor.authorGARRIGUE, Isabelle
dc.contributor.authorANGLICHEAU, Dany
dc.contributor.authorRÉROLLE, Jean-Philippe
dc.contributor.authorLE MEUR, Yannick
dc.contributor.authorDURRBACH, Antoine
dc.contributor.authorBACHELET, Thomas
dc.contributor.authorSAVEL, Helene
dc.contributor.authorCOUERON, Roxane
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorVISENTIN, Jonathan
dc.contributor.authorDEL BELLO, Arnaud
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorPELLEGRIN, Isabelle
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDECHANET-MERVILLE, Julie
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorMERVILLE, Pierre
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorTHIEBAUT, Rodolphe
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorCOUZI, Lionel
dc.date.accessioned2022-10-11T13:59:05Z
dc.date.available2022-10-11T13:59:05Z
dc.date.issued2022-01-01
dc.identifier.issn1600-6143en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/148381
dc.description.abstractEnCytomegalovirus (CMV) persists as the most frequent opportunistic infection among solid organ transplant recipients. This multicenter trial aimed to test whether treatment with everolimus (EVR) could decrease the incidence of CMV DNAemia and disease. We randomized 186 CMV seropositive kidney transplant recipients in a 1:1 ratio to receive EVR or mycophenolic acid (MPA) in association with basiliximab, cyclosporin, and steroids and 87 in each group were analyzed. No universal prophylaxis was administered to either group. The composite primary endpoint was the presence of CMV DNAemia, CMV treatment, graft loss, death, and discontinuation of the study at 6 months posttransplant. In the modified intent-to-treat analysis, 42 (48.3%) and 70 (80.5%) patients in the EVR and MPA groups reached the primary endpoint (OR = 0.21, 95% CI: 0.11-0.43, p < .0001). Fewer patients of the EVR group received treatment for CMV (21.8% vs. 47.1%, p = .0007). EVR was discontinued in 31 (35.6%) patients. Among the 56 patients with ongoing EVR treatment, only 7.4% received treatment for CMV. In conclusion, EVR prevents CMV DNAemia requiring treatment in seropositive recipients as long as it is tolerated and maintained.
dc.language.isoENen_US
dc.subject.enAntiviral Agents
dc.subject.enCytomegalovirus
dc.subject.enCytomegalovirus Infections
dc.subject.enEverolimus
dc.subject.enHumans
dc.subject.enImmunosuppressive Agents
dc.subject.enIncidence
dc.subject.enKidney Transplantation
dc.subject.enMycophenolic Acid
dc.subject.enTransplant Recipients
dc.title.enIncidence of cytomegalovirus infection in seropositive kidney transplant recipients treated with everolimus: A randomized, open-label, multicenter phase 4 trial
dc.title.alternativeAm J Transplanten_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1111/ajt.16946en_US
dc.identifier.pubmed34990047en_US
bordeaux.journalAmerican Journal of Transplantationen_US
bordeaux.page1430-1441en_US
bordeaux.volume22en_US
bordeaux.hal.laboratoriesImmunoConcepten_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.institutionINSERM
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=American%20Journal%20of%20Transplantation&amp;rft.date=2022-01-01&amp;rft.volume=22&amp;rft.issue=5&amp;rft.spage=1430-1441&amp;rft.epage=1430-1441&amp;rft.eissn=1600-6143&amp;rft.issn=1600-6143&amp;rft.au=KAMINSKI,%20Hannah&amp;KAMAR,%20Nassim&amp;THAUNAT,%20Olivier&amp;BOUVIER,%20Nicolas&amp;CAILLARD,%20Sophie&amp;rft.genre=article


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