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Cardiovascular events after a dramatic reduction of HbA1c in hospitalized subjects with type 2 diabetes and high long-term glucose exposure
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | RIGALLEAU, Vincent
IDREF: 069788146 | |
| dc.contributor.author | LARROUMET, Alice | |
| dc.contributor.author | DUCOS, Claire | |
| dc.contributor.author | RIGO, Marine | |
| dc.contributor.author | BARBET-MASSIN, Marie-Amelie | |
| dc.contributor.author | MAJCHRZAK, Camille | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MOHAMMEDI, Kamel | |
| dc.contributor.author | BAILLET-BLANCO, Laurence | |
| dc.contributor.author | MONLUN, Marie | |
| dc.contributor.author | RAMI-ARAB, Lila | |
| dc.contributor.author | FOUSSARD, Ninon | |
| dc.date.accessioned | 2022-07-15T09:25:55Z | |
| dc.date.available | 2022-07-15T09:25:55Z | |
| dc.date.issued | 2022-06-21 | |
| dc.identifier.issn | 1873-460X (Electronic) 1056-8727 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140497 | |
| dc.description.abstractEn | OBJECTIVE: In long-lasting diabetes, a dramatic reduction of HbA1c can precede adverse events such as worsening retinopathies or painful neuropathies. We have now analyzed its possible link with later cardiovascular events in subjects with type 2 diabetes, according to their long-term glucose exposure evaluated by skin autofluorescence (SAF) measured with an AGE-READER (Diagnoptics, Groningen, The Netherland). RESEARCH DESIGN AND METHODS: We studied retrospectively a cohort of patients hospitalized for uncontrolled and/or complicated type 2 diabetes from 2009 to 2017. A previous dramatic reduction of HbA1c was defined by more than -1.5 %/4 months, and later cardiovascular events as myocardial infarction, stroke, revascularization procedures, and cardiovascular-related death. Survival analyses were performed before and after categorizing the subjects for their SAF. RESULTS: The 386 subjects were 57.5 % men, 62 ± 9 years old, with a 14 ± 9 years duration of diabetes, most were treated by insulin (63.7 %). The dramatic HbA1c reducers (-3.0 ± 1.5 %) represented 16.5 % of the population. During the 51 months (IQR: 30-71) of follow-up, 53 cardiovascular events occurred and were related to the SAF (2.70 ± 0.64 AUs). Linkage was established between the SAF, the reduction of HbA1c and the cardiovascular events (p = 0.017). With a SAF higher than the median (2.65 AUs), the dramatic reduction of HbA1c was related to later cardiovascular events (HR: 3.84, 95%CI: 1.68-8.76). CONCLUSIONS: A dramatic decline of HbA1c leads to a higher risk of cardiovascular events in hospitalized subjects with type 2 diabetes and a high long-term glucose exposure. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | HbA1c | |
| dc.subject.en | Cardiovascular events | |
| dc.subject.en | Advanced glycation end products | |
| dc.subject.en | Skin autofluorescence | |
| dc.subject.en | Type 2 diabetes | |
| dc.title.en | Cardiovascular events after a dramatic reduction of HbA1c in hospitalized subjects with type 2 diabetes and high long-term glucose exposure | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1016/j.jdiacomp.2022.108234 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35752528 | en_US |
| bordeaux.journal | Journal of Diabetes and its Complications | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | LEHA_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Société Francophone du Diabète | en_US |
| hal.identifier | hal-03723824 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-07-15T09:25:58Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Diabetes%20and%20its%20Complications&rft.date=2022-06-21&rft.eissn=1873-460X%20(Electronic)%201056-8727%20(Linking)&rft.issn=1873-460X%20(Electronic)%201056-8727%20(Linking)&rft.au=RIGALLEAU,%20Vincent&LARROUMET,%20Alice&DUCOS,%20Claire&RIGO,%20Marine&BARBET-MASSIN,%20Marie-Amelie&rft.genre=article |
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