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dc.rights.licenseopenen_US
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorJOUSHOMME, Alexandre
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
hal.structure.identifierMnemonic Synergy [Mnemosyne]
dc.contributor.authorGARENNE, André
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorDUFOSSÉE, Mélody
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorRENOM, Rémy
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorRUIGROK, Hermanus Johannes
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorCHAPPE, Yann Loick
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorCANOVI, Anne
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPATRIGNONI, Lorenza
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorHURTIER, Annabelle
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPOULLETIER DE GANNES, Florence
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorLAGROYE, Isabelle
dc.contributor.authorLÉVÊQUE, Philippe
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorLEWIS, Noëlle
hal.structure.identifierInstitut de biochimie et génétique cellulaires [IBGC]
dc.contributor.authorPRIAULT, Muriel
dc.contributor.authorARNAUD-CORMOS, Delia
hal.structure.identifierLaboratoire de l'intégration, du matériau au système [IMS]
dc.contributor.authorPERCHERANCIER, Yann
dc.date.accessioned2022-07-13T08:46:58Z
dc.date.available2022-07-13T08:46:58Z
dc.date.issued2022-01
dc.identifier.issn1422-0067en_US
dc.identifier.urioai:crossref.org:10.3390/ijms23020658
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140465
dc.description.abstractEnIt remains controversial whether exposure to environmental radiofrequency signals (RF) impacts cell status or response to cellular stress such as apoptosis or autophagy. We used two label-free techniques, cellular impedancemetry and Digital Holographic Microscopy (DHM), to assess the overall cellular response during RF exposure alone, or during co-exposure to RF and chemical treatments known to induce either apoptosis or autophagy. Two human cell lines (SH-SY5Y and HCT116) and two cultures of primary rat cortex cells (astrocytes and co-culture of neurons and glial cells) were exposed to RF using an 1800 MHz carrier wave modulated with various environmental signals (GSM: Global System for Mobile Communications, 2G signal), UMTS (Universal Mobile Telecommunications System, 3G signal), LTE (Long-Term Evolution, 4G signal, and Wi-Fi) or unmodulated RF (continuous wave, CW). The specific absorption rates (S.A.R.) used were 1.5 and 6 W/kg during DHM experiments and ranged from 5 to 24 W/kg during the recording of cellular impedance. Cells were continuously exposed for three to five consecutive days while the temporal phenotypic signature of cells behavior was recorded at constant temperature. Statistical analysis of the results does not indicate that RF-EMF exposure impacted the global behavior of healthy, apoptotic, or autophagic cells, even at S.A.R. levels higher than the guidelines, provided that the temperature was kept constant.
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.sourcecrossref
dc.subject.enlabel-free techniques
dc.subject.enradiofrequency electromagnetic fields
dc.subject.enbioelectromagnetics
dc.subject.endigital holographic microscopy
dc.subject.enimpedancemetry
dc.subject.enhuman cell lines
dc.subject.enrat cortex primary cells
dc.subject.enapoptosis
dc.subject.enautophagy
dc.title.enLabel-Free Study of the Global Cell Behavior during Exposure to Environmental Radiofrequency Fields in the Presence or Absence of Pro-Apoptotic or Pro-Autophagic Treatments
dc.typeArticle de revueen_US
dc.identifier.doi10.3390/ijms23020658en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologie
bordeaux.journalInternational Journal of Molecular Medicine and Advanced Sciencesen_US
bordeaux.page658en_US
bordeaux.volume23en_US
bordeaux.hal.laboratoriesLaboratoire d’Intégration du Matériau au Système (IMS) - UMR 5218en_US
bordeaux.issue2en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionBordeaux INPen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcedissemin
hal.identifierhal-03776314
hal.version1
hal.date.transferred2022-09-13T13:51:52Z
hal.exporttrue
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
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