CD4+ T Cell Recovery and Hepatitis B Virus Coinfection in HIV-Infected Patients from Cote d'Ivoire Initiating Antiretroviral Therapy
| dc.rights.license | open | en_US |
| dc.contributor.author | HOUGHTALING, L. | |
| dc.contributor.author | MOH, Desmorys Raoul | |
| dc.contributor.author | ABDOU CHEKARAOU, M. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GABILLARD, Delphine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ANGLARET, Xavier | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | EHOLIE, Serge Paul | |
| dc.contributor.author | ZOULIM, F. | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DANEL, Christine | |
| dc.contributor.author | LACOMBE, K. | |
| dc.contributor.author | BOYD, A. | |
| dc.date.accessioned | 2020-11-17T08:23:49Z | |
| dc.date.available | 2020-11-17T08:23:49Z | |
| dc.date.issued | 2018-05 | |
| dc.identifier.issn | 1931-8405 (Electronic) 0889-2229 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/14045 | |
| dc.description.abstractEn | Immunorecovery could be attenuated in HIV-hepatitis B virus (HBV) co-infection versus HIV mono-infection during antiretroviral therapy (ART), yet whether it also occurs in individuals from Sub-Saharan Africa without severe co-morbidities is unknown. In this study, 808 HIV-infected patients in Cote d'Ivoire initiating continuous ART were included. Six-month CD4+ count trajectories and the proportion reaching CD4+ T-cell counts >350/mm3, HIV-RNA <300 copies/mL, still alive and not lost to follow-up within 18 months ("optimal immunorecovery") were compared between co-infected groups. At inclusion, 80 (9.9%) patients were HIV-HBV co-infected, 40 (50.0%) of whom had high HBV-DNA viral load (>104 copies/mL). Co-infected patients with high HBV-DNA replication initiated ART with significantly lower median CD4+ T-cell counts (216/mm3, IQR=150-286) compared to co-infection with low HBV-DNA replication (268/mm3, IQR=178-375) or HIV mono-infection (257/mm3, IQR=194-329) (p=0.003). These patients had significantly faster rates of CD4+ cell count increase from baseline after adjusting for baseline age, WHO stage III/IV and CD4+ cell counts (p=0.04), yet were not more likely to exhibit optimal immunorecovery (82.5% versus 80.0% and 77.9%, respectively) (p=0.8). In conclusion, change in CD4+ cell counts after ART-initiation was accelerated in co-infected patients with high HBV DNA viral loads, but this did not lead to increased rates of optimal immunorecovery. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | IDLIC | |
| dc.subject.en | PACCI | |
| dc.title.en | CD4+ T Cell Recovery and Hepatitis B Virus Coinfection in HIV-Infected Patients from Cote d'Ivoire Initiating Antiretroviral Therapy | |
| dc.title.alternative | AIDS Res Hum Retroviruses | en_US |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1089/aid.2017.0272 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 29466862 | en_US |
| bordeaux.journal | AIDS Research and Human Retroviruses | en_US |
| bordeaux.page | 439-445 | en_US |
| bordeaux.volume | 34 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - U1219 | en_US |
| bordeaux.issue | 5 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.team | IDLIC | en_US |
| bordeaux.team | PACCI | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03194156 | |
| hal.version | 1 | |
| hal.date.transferred | 2021-04-09T11:16:43Z | |
| hal.export | true | |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS%20Research%20and%20Human%20Retroviruses&rft.date=2018-05&rft.volume=34&rft.issue=5&rft.spage=439-445&rft.epage=439-445&rft.eissn=1931-8405%20(Electronic)%200889-2229%20(Linking)&rft.issn=1931-8405%20(Electronic)%200889-2229%20(Linking)&rft.au=HOUGHTALING,%20L.&MOH,%20Desmorys%20Raoul&ABDOU%20CHEKARAOU,%20M.&GABILLARD,%20Delphine&ANGLARET,%20Xavier&rft.genre=article |
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