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Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion
dc.rights.license | open | en_US |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | ROBERT, Benjamin J. A. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MOREAU, Maite M. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | DOS SANTOS CARVALHO, Steve | |
hal.structure.identifier | Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS] | |
dc.contributor.author | BARTHET, Gael | |
hal.structure.identifier | Newcastle University [Newcastle] | |
dc.contributor.author | RACCA, Claudia | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | BHOURI, Mehdi | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | QUIEDEVILLE, Anne | |
hal.structure.identifier | Institut de Neurosciences cognitives et intégratives d'Aquitaine [INCIA] | |
dc.contributor.author | GARRET, Maurice | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | ATCHAMA, Bénédicte | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | AL ABED, Alice Shaam | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | GUETTE, Christelle | |
hal.structure.identifier | Newcastle University [Newcastle] | |
dc.contributor.author | HENDERSON, Deborah J. | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | DESMEDT, Aline | |
hal.structure.identifier | Interdisciplinary Institute for Neuroscience [Bordeaux] [IINS] | |
hal.structure.identifier | Centre National de la Recherche Scientifique [CNRS] | |
dc.contributor.author | MULLE, Christophe | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MARIGHETTO, Aline | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | MONTCOUQUIOL, Mireille | |
hal.structure.identifier | Neurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB] | |
dc.contributor.author | SANS, Nathalie | |
dc.date.accessioned | 2022-07-11T13:56:03Z | |
dc.date.available | 2022-07-11T13:56:03Z | |
dc.date.issued | 2020-06-09 | |
dc.identifier.issn | 2211-1247 | en_US |
dc.identifier.uri | oai:crossref.org:10.1016/j.celrep.2020.107743 | |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140426 | |
dc.description.abstractEn | The organization of spatial information, including pattern completion and pattern separation processes, relies on the hippocampal circuits, yet the molecular and cellular mechanisms underlying these two processes are elusive. Here, we find that loss of Vangl2, a core PCP gene, results in opposite effects on pattern completion and pattern separation processes. Mechanistically, we show that Vangl2 loss maintains young postmitotic granule cells in an immature state, providing increased cellular input for pattern separation. The genetic ablation of Vangl2 disrupts granule cell morpho-functional maturation and further prevents CaMKII and GluA1 phosphorylation, disrupting the stabilization of AMPA receptors. As a functional consequence, LTP at lateral perforant path-GC synapses is impaired, leading to defects in pattern completion behavior. In conclusion, we show that Vangl2 exerts a bimodal regulation on young and mature GCs, and its disruption leads to an imbalance in hippocampus-dependent pattern completion and separation processes. | |
dc.description.sponsorship | Développment d'une infrastructure française distribuée coordonnée | en_US |
dc.description.sponsorship | Bordeaux Region Aquitaine Initiative for Neuroscience | en_US |
dc.description.sponsorship | Signalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiques - ANR-12-BSV4-0016 | en_US |
dc.description.sponsorship | Altérations neurobiologiques systémiques et moléculaires de la mémoire de type post-traumatique - ANR-14-CE13-0026 | en_US |
dc.language.iso | EN | en_US |
dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
dc.source | crossref | |
dc.subject.en | AMPA receptors | |
dc.subject.en | JNK | |
dc.subject.en | Cognitive processes | |
dc.subject.en | Computational function | |
dc.subject.en | Granular cells | |
dc.subject.en | Hippocampus | |
dc.subject.en | Memory | |
dc.subject.en | Noncanonical Wnt-PCP signaling | |
dc.subject.en | Plasticity | |
dc.subject.en | Polarity | |
dc.title.en | Vangl2 in the Dentate Network Modulates Pattern Separation and Pattern Completion | |
dc.title.alternative | Cell Rep. | en_US |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1016/j.celrep.2020.107743 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Neurosciences [q-bio.NC] | en_US |
dc.identifier.pubmed | 32521268 | en_US |
bordeaux.journal | Cell Reports | en_US |
bordeaux.page | 107743 | en_US |
bordeaux.volume | 31 | en_US |
bordeaux.hal.laboratories | Neurocentre Magendie - UMR-S 1215 | en_US |
bordeaux.issue | 10 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.institution | INSERM | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
bordeaux.identifier.funderID | British Heart Foundation | en_US |
bordeaux.import.source | dissemin | |
hal.export | false | |
workflow.import.source | dissemin | |
dc.rights.cc | CC BY-NC-ND | en_US |
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