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Activity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorHILAL, Muna L.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMOREAU, Maité M.
hal.structure.identifierInstitute of Neuroscience [Newcastle] [ION]
hal.structure.identifierNewcastle University [Newcastle]
dc.contributor.authorRACCA, Claudia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPINHEIRO, Vera L.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPIGUEL, Nicolas H.
hal.structure.identifierCentre de Recherche en Cancérologie de Marseille [CRCM]
hal.structure.identifierInstitut National de la Santé et de la Recherche Médicale [INSERM]
dc.contributor.authorSANTONI, Marie-Josée
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOS SANTOS CARVALHO, Steve
hal.structure.identifierPlateforme de Biochimie et de Biophysique des protéines
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBLANC, Jean-Michel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorABADA, Yah-Se K.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPEYROUTOU, Ronan
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMEDINA, Chantal
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDOAT, Hélène
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPAPOUIN, Thomas
hal.structure.identifierCentre d'Immunologie de Marseille - Luminy [CIML]
dc.contributor.authorVUILLARD, Laurent
hal.structure.identifierInstitut universitaire de France [IUF]
hal.structure.identifierCentre de Recherche en Cancérologie de Marseille [CRCM]
hal.structure.identifierInstitut Paoli-Calmettes [IPC]
hal.structure.identifierInstitut National de la Santé et de la Recherche Médicale [INSERM]
dc.contributor.authorBORG, Jean-Paul
dc.contributor.authorRACHEL, Rivka
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPANATIER, Aude
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMONTCOUQUIOL, Mireille
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorOLIET, Stéphane
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSANS, Nathalie
dc.date.accessioned2022-07-05T07:44:24Z
dc.date.available2022-07-05T07:44:24Z
dc.date.issued2017-12-22
dc.identifier.issn1047-3211en_US
dc.identifier.urioadoi:https://hal.archives-ouvertes.fr/hal-01789668/document
dc.identifier.urioadoi:https://hal.archives-ouvertes.fr/hal-01789668/file/Hilal%20et%20al_Celeb_Cortex_2016.pdf
dc.identifier.urioai:crossref.org:10.1093/cercor/bhw333
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140365
dc.description.abstractEnPlanar cell polarity (PCP) signaling is well known to play a critical role during prenatal brain development; whether it plays specific roles at postnatal stages remains rather unknown. Here, we investigated the role of a key PCP-associated gene scrib in CA1 hippocampal structure and function at postnatal stages. We found that Scrib is required for learning and memory consolidation in the Morris water maze as well as synaptic maturation and NMDAR-dependent bidirectional plasticity. Furthermore, we unveiled a direct molecular interaction between Scrib and PP1/PP2A phosphatases whose levels were decreased in postsynaptic density of conditional knock-out mice. Remarkably, exposure to enriched environment (EE) preserved memory formation in CaMK-Scrib−/− mice by recovering synaptic plasticity and maturation. Thus, Scrib is required for synaptic function involved in memory formation and EE has beneficiary therapeutic effects. Our results demonstrate a distinct new role for a PCP-associated protein, beyond embryonic development, in cognitive functions during adulthood.
dc.description.sponsorshipCaractérisations moléculaire et fonctionnelle de la protéine Scribble 1 au cours du développement du système nerveux central - ANR-07-NEUR-0031en_US
dc.description.sponsorshipSignalisation de la polarité cellulaire planaire dans la plasticité synaptique morphofonctionnelle des circuits hippocampiques - ANR-12-BSV4-0016en_US
dc.language.isoENen_US
dc.sourceoadoi_repo
dc.sourcecrossref
dc.subject.enPlanar cell polarity
dc.subject.enSynapse
dc.subject.enLTD
dc.subject.enConsolidation memory
dc.subject.enPhosphatases
dc.title.enActivity-Dependent Neuroplasticity Induced by an Enriched Environment Reverses Cognitive Deficits in Scribble Deficient Mouse
dc.title.alternativeCereb Cortexen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/cercor/bhw333en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed28968740en_US
bordeaux.journalCerebral Cortexen_US
bordeaux.page5635-5651en_US
bordeaux.volume27en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue12en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.identifier.funderIDFondation pour la Recherche Médicaleen_US
bordeaux.identifier.funderIDNewcastle Universityen_US
bordeaux.identifier.funderIDLigue Contre le Canceren_US
bordeaux.identifier.funderIDLabEx BRAINen_US
bordeaux.import.sourcedissemin
hal.exportfalse
workflow.import.sourcedissemin
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Cerebral%20Cortex&rft.date=2017-12-22&rft.volume=27&rft.issue=12&rft.spage=5635-5651&rft.epage=5635-5651&rft.eissn=1047-3211&rft.issn=1047-3211&rft.au=HILAL,%20Muna%20L.&MOREAU,%20Mait%C3%A9%20M.&RACCA,%20Claudia&PINHEIRO,%20Vera%20L.&PIGUEL,%20Nicolas%20H.&rft.genre=article


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