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The risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies

dc.rights.licenseopenen_US
dc.contributor.authorMANRY, Jeremy
dc.contributor.authorBASTARD, Paul
dc.contributor.authorGERVAIS, Adrian
dc.contributor.authorLE VOYER, Tom
dc.contributor.authorROSAIN, Jeremie
dc.contributor.authorPHILIPPOT, Quentin
dc.contributor.authorMICHAILIDIS, Eleftherios
dc.contributor.authorHOFFMANN, Hans-Heinrich
dc.contributor.authorETO, Shohei
dc.contributor.authorGARCIA-PRAT, Marina
dc.contributor.authorBIZIEN, Lucy
dc.contributor.authorPARRA-MARTINEZ, Alba
dc.contributor.authorYANG, Rui
dc.contributor.authorHALJASMAGI, Liis
dc.contributor.authorMIGAUD, Melanie
dc.contributor.authorSAREKANNU, Karita
dc.contributor.authorMASLOVSKAJA, Julia
dc.contributor.authorDE PROST, Nicolas
dc.contributor.authorTANDJAOUI-LAMBIOTTE, Yacine
dc.contributor.authorLUYT, Charles-Edouard
dc.contributor.authorAMADOR-BORRERO, Blanca
dc.contributor.authorGAUDET, Alexandre
dc.contributor.authorPOISSY, JULIEN
dc.contributor.authorMOREL, Pascal
dc.contributor.authorRICHARD, Pascale
dc.contributor.authorCOGNASSE, Fabrice
dc.contributor.authorTROYA, Jesus
dc.contributor.authorTROUILLET-ASSANT, Sophie
dc.contributor.authorBELOT, Alexandre
dc.contributor.authorSAKER, Kahina
dc.contributor.authorGARCON, Pierre
dc.contributor.authorRIVIERE, Jacques G.
dc.contributor.authorLAGIER, Jean-Christophe
dc.contributor.authorGENTILE, Stephanie
dc.contributor.authorROSEN, Lindsey B.
dc.contributor.authorSHAW, Elana
dc.contributor.authorMORIO, Tomohiro
dc.contributor.authorTANAKA, Junko
dc.contributor.authorDALMAU, David
dc.contributor.authorTHARAUX, Pierre-Louis
dc.contributor.authorSENE, Damien
dc.contributor.authorSTEPANIAN, Alain
dc.contributor.authorMEGARBANE, Bruno
dc.contributor.authorTRIANTAFYLLIA, Vasiliki
dc.contributor.authorFEKKAR, Arnaud
dc.contributor.authorHEATH, James R.
dc.contributor.authorFRANCO, Jose Luis
dc.contributor.authorANAYA, Juan-Manuel
dc.contributor.authorSOLE-VIOLAN, Jordi
dc.contributor.authorIMBERTI, Luisa
dc.contributor.authorBIONDI, Andrea
dc.contributor.authorBONFANTI, Paolo
dc.contributor.authorCASTAGNOLI, Riccardo
dc.contributor.authorDELMONTE, Ottavia M.
dc.contributor.authorZHANG, Yu
dc.contributor.authorSNOW, Andrew L.
dc.contributor.authorHOLLAND, Steven M.
dc.contributor.authorBIGGS, Catherine M.
dc.contributor.authorMONCADA-VELEZ, Marcela
dc.contributor.authorARIAS, Andres Augusto
dc.contributor.authorLORENZO, Lazaro
dc.contributor.authorBOUCHERIT, Soraya
dc.contributor.authorANGLICHEAU, Dany
dc.contributor.authorPLANAS, Anna M.
dc.contributor.authorHAERYNCK, Filomeen
dc.contributor.authorDUVLIS, Sotirija
dc.contributor.authorOZCELIK, Tayfun
dc.contributor.authorKELES, Sevgi
dc.contributor.authorBOUSFIHA, Ahmed A.
dc.contributor.authorEL BAKKOURI, Jalila
dc.contributor.authorRAMIREZ-SANTANA, Carolina
dc.contributor.authorPAUL, Stephane
dc.contributor.authorPAN-HAMMARSTROM, Qiang
dc.contributor.authorHAMMARSTROM, Lennart
dc.contributor.authorDUPONT, Annabelle
dc.contributor.authorKUROLAP, Alina
dc.contributor.authorMETZ, Christine N.
dc.contributor.authorAIUTI, Alessandro
dc.contributor.authorCASARI, Giorgio
dc.contributor.authorLAMPASONA, Vito
dc.contributor.authorCICERI, Fabio
dc.contributor.authorBARREIROS, Lucila A.
dc.contributor.authorDOMINGUEZ-GARRIDO, Elena
dc.contributor.authorVIDIGAL, Mateus
dc.contributor.authorZATZ, Mayana
dc.contributor.authorVAN DE BEEK, Diederik
dc.contributor.authorSAHANIC, Sabina
dc.contributor.authorTANCEVSKI, Ivan
dc.contributor.authorSTEPANOVSKYY, Yurii
dc.contributor.authorBOYARCHUK, Oksana
dc.contributor.authorNUKUI, Yoko
dc.contributor.authorTSUMURA, Miyuki
dc.contributor.authorVIDAUR, Loreto
dc.contributor.authorTANGYE, Stuart G.
dc.contributor.authorBURREL, Sonia
dc.contributor.authorDUFFY, Darragh
dc.contributor.authorQUINTANA-MURCI, Lluis
dc.contributor.authorKLOCPERK, Adam
dc.contributor.authorKANN, Nelli Y.
dc.contributor.authorSHCHERBINA, Anna
dc.contributor.authorLAU, Yu-Lung
dc.contributor.authorLEUNG, Daniel
dc.contributor.authorCOULONGEAT, Matthieu
dc.contributor.authorMARLET, Julien
dc.contributor.authorKONING, Rutger
dc.contributor.authorREYES, Luis Felipe
dc.contributor.authorCHAUVINEAU-GRENIER, Angelique
dc.contributor.authorVENET, Fabienne
dc.contributor.authorMONNERET, Guillaume
dc.contributor.authorNUSSENZWEIG, Michel C.
dc.contributor.authorARRESTIER, Romain
dc.contributor.authorBOUDHABHAY, Idris
dc.contributor.authorBARIS-FELDMAN, Hagit
dc.contributor.authorHAGIN, David
dc.contributor.authorWAUTERS, Joost
dc.contributor.authorMEYTS, Isabelle
dc.contributor.authorDYER, Adam H.
dc.contributor.authorKENNELLY, Sean P.
dc.contributor.authorBOURKE, Nollaig M.
dc.contributor.authorHALWANI, Rabih
dc.contributor.authorSHARIF-ASKARI, Fatemeh Saheb
dc.contributor.authorDORGHAM, Karim
dc.contributor.authorSALLETTE, Jerome
dc.contributor.authorSEDKAOUI, Souad Mehlal
dc.contributor.authorALKHATER, Suzan
dc.contributor.authorRIGO-BONNIN, Raul
dc.contributor.authorMORANDEIRA, Francisco
dc.contributor.authorROUSSEL, Lucie
dc.contributor.authorVINH, Donald C.
dc.contributor.authorERIKSTRUP, Christian
dc.contributor.authorCONDINO-NETO, Antonio
dc.contributor.authorPRANDO, Carolina
dc.contributor.authorBONDARENKO, Anastasiia
dc.contributor.authorSPAAN, Andras N.
dc.contributor.authorGILARDIN, Laurent
dc.contributor.authorFELLAY, Jacques
dc.contributor.authorLYONNET, Stanislas
dc.contributor.authorBILGUVAR, Kaya
dc.contributor.authorLIFTON, Richard P.
dc.contributor.authorMANE, Shrikant
dc.contributor.authorANDERSON, Mark S.
dc.contributor.authorBOISSON, Bertrand
dc.contributor.authorBEZIAT, Vivien
dc.contributor.authorZHANG, Shen-Ying
dc.contributor.authorANDREAKOS, Evangelos
dc.contributor.authorHERMINE, Olivier
dc.contributor.authorPUJOL, Aurora
dc.contributor.authorPETERSON, Part
dc.contributor.authorMOGENSEN, Trine H.
dc.contributor.authorROWEN, Lee
dc.contributor.authorMOND, James
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorDEBETTE, Stephanie
dc.contributor.authorDE LAMBALLERIE, Xavier
dc.contributor.authorBURDET, Charles
dc.contributor.authorBOUADMA, Lila
dc.contributor.authorZINS, Marie
dc.contributor.authorSOLER-PALACIN, Pere
dc.contributor.authorCOLOBRAN, Roger
dc.contributor.authorGOROCHOV, Guy
dc.contributor.authorSOLANICH, Xavier
dc.contributor.authorSUSEN, Sophie
dc.contributor.authorMARTINEZ-PICADO, Javier
dc.contributor.authorRAOULT, Didier
dc.contributor.authorVASSE, Marc
dc.contributor.authorGREGERSEN, Peter K.
dc.contributor.authorPIEMONTI, Lorenzo
dc.contributor.authorRODRIGUEZ-GALLEGO, Carlos
dc.contributor.authorNOTARANGELO, Luigi D.
dc.contributor.authorSU, Helen C.
dc.contributor.authorKISAND, Kai
dc.contributor.authorOKADA, Satoshi
dc.contributor.authorPUEL, Anne
dc.contributor.authorJOUANGUY, Emmanuelle
dc.contributor.authorRICE, Charles M.
dc.contributor.authorTIBERGHIEN, Pierre
dc.contributor.authorZHANG, Qian
dc.contributor.authorCASANOVA, Jean-Laurent
dc.contributor.authorABEL, Laurent
dc.contributor.authorCOBAT, Aurelie
dc.date.accessioned2022-06-21T14:04:34Z
dc.date.available2022-06-21T14:04:34Z
dc.date.issued2022-05-16
dc.identifier.issn1091-6490 (Electronic) 0027-8424 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140297
dc.description.abstractEnSignificanceThere is growing evidence that preexisting autoantibodies neutralizing type I interferons (IFNs) are strong determinants of life-threatening COVID-19 pneumonia. It is important to estimate their quantitative impact on COVID-19 mortality upon SARS-CoV-2 infection, by age and sex, as both the prevalence of these autoantibodies and the risk of COVID-19 death increase with age and are higher in men. Using an unvaccinated sample of 1,261 deceased patients and 34,159 individuals from the general population, we found that autoantibodies against type I IFNs strongly increased the SARS-CoV-2 infection fatality rate at all ages, in both men and women. Autoantibodies against type I IFNs are strong and common predictors of life-threatening COVID-19. Testing for these autoantibodies should be considered in the general population.
dc.language.isoENen_US
dc.rightsAttribution 3.0 International (CC BY 3.0)
dc.rightsAttribution 3.0 International (CC BY 3.0)
dc.rights.urihttps://creativecommons.org/licenses/by/3.0/
dc.title.enThe risk of COVID-19 death is much greater and age dependent with type I IFN autoantibodies
dc.typeArticle de revueen_US
dc.identifier.doi10.1073/pnas.2200413119en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35576468en_US
bordeaux.journalProceedings of the National Academy of Sciences of the United States of Americaen_US
bordeaux.volume119en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue21en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamELEANOR_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03701064
hal.version1
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Proceedings%20of%20the%20National%20Academy%20of%20Sciences%20of%20the%20United%20States%20of%20America&rft.date=2022-05-16&rft.volume=119&rft.issue=21&rft.eissn=1091-6490%20(Electronic)%200027-8424%20(Linking)&rft.issn=1091-6490%20(Electronic)%200027-8424%20(Linking)&rft.au=MANRY,%20Jeremy&BASTARD,%20Paul&GERVAIS,%20Adrian&LE%20VOYER,%20Tom&ROSAIN,%20Jeremie&rft.genre=article


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