Afficher la notice abrégée

Trajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation

dc.rights.licenseauthentificationen_US
dc.contributor.authorRAYNAUD, Marc
dc.contributor.authorAUBERT, Olivier
dc.contributor.authorREESE, Peter P.
dc.contributor.authorBOUATOU, Yassine
dc.contributor.authorNAESENS, Maarten
dc.contributor.authorKAMAR, Nassim
dc.contributor.authorBAILLY, Elodie
dc.contributor.authorGIRAL, Magali
dc.contributor.authorLADRIERE, Marc
dc.contributor.authorLE QUINTREC, Moglie
dc.contributor.authorDELAHOUSSE, Michel
dc.contributor.authorJURIC, Ivana
dc.contributor.authorBASIC-JUKIC, Nikolina
dc.contributor.authorGUPTA, Gaurav
dc.contributor.authorAKALIN, Enver
dc.contributor.authorYOO, Daniel
dc.contributor.authorCHIN, Chen-Shan
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
dc.contributor.authorBOHMIG, Georg
dc.contributor.authorOBERBAUER, Rainer
dc.contributor.authorSTEGALL, Mark D.
dc.contributor.authorBENTALL, Andrew J.
dc.contributor.authorJORDAN, Stanley C.
dc.contributor.authorHUANG, Edmund
dc.contributor.authorGLOTZ, Denis
dc.contributor.authorLEGENDRE, Christophe
dc.contributor.authorMONTGOMERY, Robert A.
dc.contributor.authorSEGEV, Dorry L.
dc.contributor.authorEMPANA, Jean-Philippe
dc.contributor.authorGRAMS, Morgan E.
dc.contributor.authorCORESH, Josef
dc.contributor.authorJOUVEN, Xavier
dc.contributor.authorLEFAUCHEUR, Carmen
dc.contributor.authorLOUPY, Alexandre
dc.date.accessioned2022-06-16T12:38:28Z
dc.date.available2022-06-16T12:38:28Z
dc.date.issued2021-01
dc.identifier.issn0085-2538en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140240
dc.description.abstractEnAlthough the gold standard of monitoring kidney transplant function relies on glomerular filtration rate (GFR), little is known about GFR trajectories after transplantation, their determinants, and their association with outcomes. To evaluate these parameters we examined kidney transplant recipients receiving care at 15 academic centers. Patients underwent prospective monitoring of estimated GFR (eGFR) measurements, with assessment of clinical, functional, histological and immunological parameters. Additional validation took place in seven randomized controlled trials that included a total of 14,132 patients with 403,497 eGFR measurements. After a median follow-up of 6.5 years, 1,688 patients developed end-stage kidney disease. Using unsupervised latent class mixed models, we identified eight distinct eGFR trajectories. Multinomial regression models identified seven significant determinants of eGFR trajectories including donor age, eGFR, proteinuria, and several significant histological features: graft scarring, graft interstitial inflammation and tubulitis, microcirculation inflammation, and circulating anti-HLA donor specific antibodies. The eGFR trajectories were associated with progression to end stage kidney disease. These trajectories, their determinants and respective associations with end stage kidney disease were similar across cohorts, as well as in diverse clinical scenarios, therapeutic eras and in the seven randomized control trials. Thus, our results provide the basis for a trajectory-based assessment of kidney transplant patients for risk stratification and monitoring.
dc.language.isoENen_US
dc.subject.enend-stage renal disease
dc.subject.englomerular filtration rate
dc.subject.enkidney function
dc.subject.enkidney transplantation
dc.subject.enmortality
dc.subject.entrajectories
dc.title.enTrajectories of glomerular filtration rate and progression to end stage kidney disease after kidney transplantation
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.kint.2020.07.025en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed2781106en_US
bordeaux.journalKidney Internationalen_US
bordeaux.page186 - 197en_US
bordeaux.volume99en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Kidney%20International&rft.date=2021-01&rft.volume=99&rft.spage=186%20-%20197&rft.epage=186%20-%20197&rft.eissn=0085-2538&rft.issn=0085-2538&rft.au=RAYNAUD,%20Marc&AUBERT,%20Olivier&REESE,%20Peter%20P.&BOUATOU,%20Yassine&NAESENS,%20Maarten&rft.genre=article


Fichier(s) constituant ce document

FichiersTailleFormatVue

Il n'y a pas de fichiers associés à ce document.

Ce document figure dans la(les) collection(s) suivante(s)

Afficher la notice abrégée