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Long-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS

dc.rights.licenseopenen_US
dc.contributor.authorMOITRA, Subhabrata
dc.contributor.authorCARSIN, Anne-Elie
dc.contributor.authorABRAMSON, Michael J.
dc.contributor.authorACCORDINI, Simone
dc.contributor.authorAMARAL, Andre F. S.
dc.contributor.authorANTO, Josep
dc.contributor.authorBONO, Roberto
dc.contributor.authorCASAS RUIZ, Lidia
dc.contributor.authorCERVERI, Isa
dc.contributor.authorCHATZI, Leda
dc.contributor.authorDEMOLY, Pascal
dc.contributor.authorDORADO-ARENAS, Sandra
dc.contributor.authorFORSBERG, Bertil
dc.contributor.authorGILLILAND, Frank
dc.contributor.authorGISLASON, Thorarinn
dc.contributor.authorGULLON, Jose A.
dc.contributor.authorHEINRICH, Joachim
dc.contributor.authorHOLM, Mathias
dc.contributor.authorJANSON, Christer
dc.contributor.authorJOGI, Rain
dc.contributor.authorGOMEZ REAL, Francisco
dc.contributor.authorJARVIS, Debbie
dc.contributor.authorLEYNAERT, Benedicte
dc.contributor.authorNOWAK, Dennis
dc.contributor.authorPROBST-HENSCH, Nicole
dc.contributor.authorSANCHEZ-RAMOS, Jose Luis
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRAHERISON-SEMJEN, Chantal
dc.contributor.authorSIROUX, Valerie
dc.contributor.authorGUERRA, Stefano
dc.contributor.authorKOGEVINAS, Manolis
dc.contributor.authorGARCIA-AYMERICH, Judith
dc.date.accessioned2022-06-10T09:07:31Z
dc.date.available2022-06-10T09:07:31Z
dc.date.issued2023-02-27
dc.identifier.issn1468-3296 (Electronic) 0040-6376 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140185
dc.description.abstractEnINTRODUCTION: Obesity is a known risk factor for asthma. Although some evidence showed asthma causing obesity in children, the link between asthma and obesity has not been investigated in adults. METHODS: We used data from the European Community Respiratory Health Survey (ECRHS), a cohort study in 11 European countries and Australia in 3 waves between 1990 and 2014, at intervals of approximately 10 years. We considered two study periods: from ECRHS I (t) to ECRHS II (t+1), and from ECRHS II (t) to ECRHS III (t+1). We excluded obese (body mass index≥30 kg/m(2)) individuals at visit t. The relative risk (RR) of obesity at t+1 associated with asthma at t was estimated by multivariable modified Poisson regression (lag) with repeated measurements. Additionally, we examined the association of atopy and asthma medication on the development of obesity. RESULTS: We included 7576 participants in the period ECRHS I-II (51.5% female, mean (SD) age of 34 (7) years) and 4976 in ECRHS II-III (51.3% female, 42 (8) years). 9% of participants became obese in ECRHS I-II and 15% in ECRHS II-III. The risk of developing obesity was higher among asthmatics than non-asthmatics (RR 1.22, 95% CI 1.07 to 1.38), and particularly higher among non-atopic than atopic (1.47; 1.17 to 1.86 vs 1.04; 0.86 to 1.27), those with longer disease duration (1.32; 1.10 to 1.59 in >20 years vs 1.12; 0.87 to 1.43 in ≤20 years) and those on oral corticosteroids (1.99; 1.26 to 3.15 vs 1.15; 1.03 to 1.28). Physical activity was not a mediator of this association. CONCLUSION: This is the first study showing that adult asthmatics have a higher risk of developing obesity than non-asthmatics, particularly those non-atopic, of longer disease duration or on oral corticosteroids.
dc.language.isoENen_US
dc.title.enLong-term effect of asthma on the development of obesity among adults: an international cohort study, ECRHS
dc.typeArticle de revueen_US
dc.identifier.doi10.1136/thoraxjnl-2021-217867en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35477559en_US
bordeaux.journalThoraxen_US
bordeaux.page128-135
bordeaux.volume78
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue2
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03693071
hal.version1
hal.date.transferred2022-06-10T09:07:34Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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