Monitoring of SARS-CoV-2 in wastewater: what normalisation for improved understanding of epidemic trends?
| dc.rights.license | open | en_US |
| dc.contributor.author | SAKAROVITCH, Charlotte | |
| dc.contributor.author | SCHLOSSER, Olivier | |
| dc.contributor.author | COURTOIS, Sophie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PROUST LIMA, Cecile
ORCID: 0000-0002-9884-955X IDREF: 114375747 | |
| dc.contributor.author | COUALLIER, Joanne | |
| dc.contributor.author | PETRAU, Agnes | |
| dc.contributor.author | LITRICO, Xavier | |
| dc.contributor.author | LORET, Jean-Francois | |
| dc.date.accessioned | 2022-05-16T11:48:13Z | |
| dc.date.available | 2022-05-16T11:48:13Z | |
| dc.date.issued | 2022-04-01 | |
| dc.identifier.issn | 1477-8920 (Print) 1477-8920 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/140066 | |
| dc.description.abstractEn | SARS-CoV-2 RNA quantification in wastewater has emerged as a relevant additional means to monitor the COVID-19 pandemic. However, the concentration can be affected by black water dilution factors or movements of the sewer shed population, leading to misinterpretation of measurement results. The aim of this study was to evaluate the performance of different indicators to accurately interpret SARS-CoV-2 in wastewater. Weekly/bi-weekly measurements from three cities in France were analysed from February to September 2021. The concentrations of SARS-CoV-2 gene copies were normalised to the faecal-contributing population using simple sewage component indicators. To reduce the measurement error, a composite index was created to combine simultaneously the information carried by the simple indicators. The results showed that the regularity (mean absolute difference between observation and the smoothed curve) of the simple indicators substantially varied across sampling points. The composite index consistently showed better regularity compared to the other indicators and was associated to the lowest variation in correlation coefficient across sampling points. These findings suggest the recommendation for the use of a composite index in wastewater-based epidemiology to compensate for variability in measurement results. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution-NonCommercial-NoDerivs 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by-nc-nd/3.0/us/ | * |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Normalisation | |
| dc.subject.en | SARS-CoV-2 | |
| dc.subject.en | Wastewater-based epidemiology | |
| dc.subject.en | Wastewater monitoring | |
| dc.title.en | Monitoring of SARS-CoV-2 in wastewater: what normalisation for improved understanding of epidemic trends? | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.2166/wh.2022.012 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35482387 | en_US |
| bordeaux.journal | Journal of Water and Health | en_US |
| bordeaux.page | 712-726 | en_US |
| bordeaux.volume | 20 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 4 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | BIOSTAT_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03669140 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-05-16T11:48:21Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
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