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Overall and net survival of patients with sarcoma between 2005 and 2010: Results from the French Network of Cancer Registries (FRANCIM)

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMADEO, Brice
dc.contributor.authorPENEL, Nicolas
dc.contributor.authorCOINDRE, Jean-Michel
dc.contributor.authorRAY-COQUARD, Isabelle
dc.contributor.authorPLOUVIER, Sandrine
dc.contributor.authorDELAFOSSE, Patricia
dc.contributor.authorBOUVIER, Anne-Marie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALLET, Justine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLACOURT, Aude
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGALVIN, Angeline
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUREAU, Gaelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMONNEREAU, Alain
dc.contributor.authorBLAY, Jean-Yves
dc.contributor.authorDESANDES, Emmanuel
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorMATHOULIN-PELISSIER, Simone
dc.date.accessioned2022-05-16T10:05:42Z
dc.date.available2022-05-16T10:05:42Z
dc.date.issued2022-04-06
dc.identifier.issn1097-0142 (Electronic) 0008-543X (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/140065
dc.description.abstractEnBACKGROUND: Sarcomas are rare, heterogeneous, ubiquitously localized malignancies with many histologic subtypes and genomic patterns. The survival of patients with sarcoma has rarely been described based on this heterogeneity; therefore, the authors' objective was to estimate survival outcomes in patients who had sarcomas using the 2020 version of the World Health Organization classification of soft tissue and bone tumors. METHODS: Patients older than 15 years who had incident sarcoma diagnosed between 2005 and 2010 were extracted from 14 French population-based cancer registries covering 18% of the French metropolitan population. Vital status for each patient was actively followed up to June 30, 2013. Net survival (NS) was estimated using the unbiased Pohar-Perme method. RESULTS: Overall, 4202 patients were included. NS declined with increasing age at diagnosis. According to topographic groups, large 5-year NS disparities were observed, ranging from 47% among women with gynecologic sarcomas to 89% among patients with skin sarcomas. Patients with soft tissue, bone, and gastrointestinal sarcomas had 5-year NS rates of 53%, 61%, and 70%, respectively. Similar heterogeneity was observed according to histologic subtypes, with 5-year NS ranging from 19% for patients with angiosarcomas to 96% for patients with dermatofibrosarcomas. Patients with sarcoma who displayed missense mutations had a better 5-year NS (74%); those with MDM2-amplified sarcomas had the worst NS (45%). CONCLUSIONS: NS rates in patients with sarcoma are presented here for the first time based on the 2020 World Health Organization classification applied to population-based registry data. Large prognostic heterogeneity was observed based on age, topographic and histologic groups, and genomic alteration profiles, constituting a benchmark for future studies and clinical trials.
dc.language.isoENen_US
dc.subject.enCancer registry
dc.subject.enFrance
dc.subject.enFrench Network of Cancer Registries (FRANCIM network)
dc.subject.enSarcoma
dc.subject.enSurvival
dc.title.enOverall and net survival of patients with sarcoma between 2005 and 2010: Results from the French Network of Cancer Registries (FRANCIM)
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/cncr.34217en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35385134en_US
bordeaux.journalCanceren_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamEPICENE_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03669030
hal.version1
hal.date.transferred2022-05-16T10:05:54Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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