Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies
| dc.rights.license | open | en_US |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | GIRAUD, Julie | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | CHALOPIN, Domitille | |
| dc.contributor.author | BLANC, J.-F. | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation [ImmunoConcept] | |
| dc.contributor.author | SALEH, Maya | |
| dc.date.accessioned | 2022-05-04T08:33:24Z | |
| dc.date.available | 2022-05-04T08:33:24Z | |
| dc.date.issued | 2021-03-18 | |
| dc.identifier.issn | 1664-3224 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139977 | |
| dc.description.abstractEn | Hepatocellular carcinoma (HCC) is the most common liver tumor and among the deadliest cancers worldwide. Advanced HCC overall survival is meager and has not improved over the last decade despite approval of several tyrosine kinase inhibitors (TKi) for first and second-line treatments. The recent approval of immune checkpoint inhibitors (ICI) has revolutionized HCC palliative care. Unfortunately, the majority of HCC patients fail to respond to these therapies. Here, we elaborate on the immune landscapes of the normal and cirrhotic livers and of the unique HCC tumor microenvironment. We describe the molecular and immunological classifications of HCC, discuss the role of specific immune cell subsets in this cancer, with a focus on myeloid cells and pathways in anti-tumor immunity, tumor promotion and immune evasion. We also describe the challenges and opportunities of immunotherapies in HCC and discuss new avenues based on harnessing the anti-tumor activity of myeloid, NK and ?? T cells, vaccines, chimeric antigen receptors (CAR)-T or -NK cells, oncolytic viruses, and combination therapies. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Cirrhosis | |
| dc.subject.en | Immune checkpoint inhibitors | |
| dc.subject.en | Immunosuppression | |
| dc.subject.en | Immunotherapy | |
| dc.subject.en | Inflammation | |
| dc.subject.en | NASH | |
| dc.subject.en | Tumor microenvironment | |
| dc.subject.en | Tumor-associated macrophages | |
| dc.title.en | Hepatocellular Carcinoma Immune Landscape and the Potential of Immunotherapies | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fimmu.2021.655697 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
| dc.identifier.pubmed | 33815418 | en_US |
| bordeaux.journal | Frontiers in Immunology | en_US |
| bordeaux.volume | 12 | en_US |
| bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | CNRS | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Fondation ARC pour la Recherche sur le Cancer | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| hal.export | false | |
| dc.rights.cc | CC BY | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Immunology&rft.date=2021-03-18&rft.volume=12&rft.eissn=1664-3224&rft.issn=1664-3224&rft.au=GIRAUD,%20Julie&CHALOPIN,%20Domitille&BLANC,%20J.-F.&SALEH,%20Maya&rft.genre=article |
