Efficacy of plasmapheresis and semi-selective immunoadsorption for removal of anti-HLA antibodies
dc.rights.license | open | en_US |
dc.contributor.author | JAMBON, Frederic | |
dc.contributor.author | MERVILLE, Pierre | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | GUIDICELLI, G. | |
dc.contributor.author | TATON, B. | |
dc.contributor.author | DE PRECIGOUT, V. | |
dc.contributor.author | COUZI, Lionel | |
dc.contributor.author | MOREAU, K. | |
hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
dc.contributor.author | VISENTIN, Jonathan | |
dc.date.accessioned | 2022-05-03T13:53:55Z | |
dc.date.available | 2022-05-03T13:53:55Z | |
dc.date.issued | 2021-06 | |
dc.identifier.issn | 1098-1101 (online) 0733-2459 (print) | en_US |
dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139973 | |
dc.description.abstractEn | Background: In organ transplantation, apheresis is frequently used for removal of anti-HLA antibodies. However, it is unclear whether plasmapheresis (PP) or semi-selective immunoadsorption (IA) should be employed, and the optimal number of apheresis sessions required to reach post-treatment objectives is also unknown. Methods: We enrolled 43 patients from Bordeaux University Hospital who were treated with PP (n=29) or IA (n=14) for antibody-mediated rejection or pre-transplant desensitization. Using Luminex single-antigen flow beads, we assessed the initial mean fluorescence intensity (MFI) of 1416 positive beads with MFIs obtained after 7 to 8 apheresis sessions (extended protocol) and, if a serum was available, after the first four sessions (short protocol). Results: MFI reduction after extended apheresis protocol was stronger with IA [87% (61%-100%)] than with PP [73% (22%-100%)] (P <.001). Indeed, 59% of the beads had a final MFI < 2000 with IA, whereas only 38% with PP (P <.001). The efficacy of removal depended on initial MFI but not on HLA specificity. A short protocol of apheresis showed excellent results without superiority of IA over PP for antibodies with an initial MFI < 3000. For antibodies showing MFI ?2000 after four sessions, the residual MFI predicted the effectiveness of four additional sessions. Conclusion: Monitoring the MFI of anti-HLA antibodies before and during apheresis protocol can guide physicians in the selection of apheresis technique and the number of sessions to be performed. | |
dc.language.iso | EN | en_US |
dc.subject.en | Anti-HLA antibodies | |
dc.subject.en | Immunoadsorption | |
dc.subject.en | Organ transplantation | |
dc.subject.en | Plasmapheresis | |
dc.title.en | Efficacy of plasmapheresis and semi-selective immunoadsorption for removal of anti-HLA antibodies | |
dc.type | Article de revue | en_US |
dc.identifier.doi | 10.1002/jca.21858 | en_US |
dc.subject.hal | Sciences du Vivant [q-bio]/Immunologie | en_US |
dc.identifier.pubmed | 33253430 | en_US |
bordeaux.journal | Journal of Clinical Apheresis | en_US |
bordeaux.page | 291-298 | en_US |
bordeaux.volume | 36 | en_US |
bordeaux.hal.laboratories | ImmunoConcEpT - UMR 5164 | en_US |
bordeaux.issue | 3 | en_US |
bordeaux.institution | Université de Bordeaux | en_US |
bordeaux.institution | CNRS | en_US |
bordeaux.peerReviewed | oui | en_US |
bordeaux.inpress | non | en_US |
hal.identifier | hal-03658146 | |
hal.version | 1 | |
hal.date.transferred | 2022-05-03T13:53:56Z | |
hal.export | true | |
dc.rights.cc | Pas de Licence CC | en_US |
bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Clinical%20Apheresis&rft.date=2021-06&rft.volume=36&rft.issue=3&rft.spage=291-298&rft.epage=291-298&rft.eissn=1098-1101%20(online)%200733-2459%20(print)&rft.issn=1098-1101%20(online)%200733-2459%20(print)&rft.au=JAMBON,%20Frederic&MERVILLE,%20Pierre&GUIDICELLI,%20G.&TATON,%20B.&DE%20PRECIGOUT,%20V.&rft.genre=article |
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