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MUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression

dc.rights.licenseopenen_US
dc.contributor.authorJUGE, Pierre-Antoine
dc.contributor.authorSOLOMON, Joshua J
dc.contributor.authorVAN MOORSEL, C.H.M.
dc.contributor.authorGAROFOLI, R.
dc.contributor.authorLEE, J.S.
dc.contributor.authorLOUIS-SYDNEY, F.
dc.contributor.authorROJAS-SERRANO, J.
dc.contributor.authorGONZALEZ-PEREZ, M.I.
dc.contributor.authorMEJIA, M.
dc.contributor.authorBUENDIA-ROLDAN, I.
dc.contributor.authorFALFAN-VALENCIA, R.
dc.contributor.authorAMBROCIO-ORTIZ, E.
dc.contributor.authorMANALI, E.
dc.contributor.authorPAPIRIS, S.A.
dc.contributor.authorKARAGEORGAS, T.
dc.contributor.authorBOUMPAS, D.
dc.contributor.authorANTONIOU, K.M.
dc.contributor.authorSIDIROPOULOS, P.
dc.contributor.authorTRACHALAKI, A.
dc.contributor.authorVAN DER VIS, J.J.
dc.contributor.authorJAMNITSKI, A.
dc.contributor.authorGRUTTERS, J.C.
dc.contributor.authorKANNENGIESSER, C.
dc.contributor.authorBORIE, R.
dc.contributor.authorKAWANO-DOURADO, L.
dc.contributor.authorWEMEAU-STERVINOU, L.
dc.contributor.authorFLIPO, R.-M.
dc.contributor.authorNUNES, H.
dc.contributor.authorUZUNHAN, Y.
dc.contributor.authorVALEYRE, D.
dc.contributor.authorSAIDENBERG-KERMANAC'H, N.
dc.contributor.authorBOISSIER, M.-C.
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierHôpital Pellegrin
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierCHU Bordeaux
hal.structure.identifierCHU de Bordeaux Pellegrin [Bordeaux]
hal.structure.identifierService de Rhumatologie [CHU Pellegrin]
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
hal.structure.identifierAquitaine’s Care and Research organisation for inflammatory and Immune-Mediated diseases [CHU Bordeaux] [FHU ACRONIM]
dc.contributor.authorRICHEZ, Christophe
hal.structure.identifierComposantes innées de la réponse immunitaire et différenciation [CIRID]
hal.structure.identifierHôpital Pellegrin
hal.structure.identifierService de rhumatologie
hal.structure.identifierUniversité de Bordeaux [UB]
hal.structure.identifierDépartement de Rhumatologie
hal.structure.identifierCHU Bordeaux
hal.structure.identifierService de Rhumatologie [CHU Pellegrin]
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorSCHAEVERBEKE, Thierry
dc.contributor.authorDOYLE, T.
dc.contributor.authorWOLTERS, P.J.
dc.contributor.authorDEBRAY, M.-P.
dc.contributor.authorBOILEAU, C.
dc.contributor.authorPORCHER, R.
dc.contributor.authorSCHWARTZ, D.A.
dc.contributor.authorCRESTANI, B.
dc.contributor.authorDIEUDE, P.
dc.date.accessioned2022-05-02T08:07:38Z
dc.date.available2022-05-02T08:07:38Z
dc.date.issued2021
dc.identifier.issn0049-0172en_US
dc.identifier.other10.1016/j.semarthrit.2021.07.002.en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/139946
dc.description.abstractEnBackground: The major risk factor for idiopathic pulmonary fibrosis (IPF), MUC5B rs35705950, was found to be associated with rheumatoid arthritis-associated interstitial lung disease (RA-ILD). Whilst the MUC5B rs35705950 T risk allele has been associated with better survival in IPF, its impact on RA-ILD prognosis remains to be determined. Our objective was to explore the influence of MUC5B rs35705950 on survival and progression in RA-ILD. Methods: Through an international retrospective observational study, patients with RA-ILD were genotyped for the MUC5B rs35705950 variant and consecutive pulmonary function tests (PFTs) findings were collected. Longitudinal data up to a 10-year follow-up were considered and analyzed using mixed regression models. Proportional hazards and joint proportional hazards models were used to analyze the association of baseline and longitudinal variables with lung transplant-free survival. Significant progression of RA-ILD was defined as at least an absolute or relative 10% decline of forced vital capacity at 2 years from baseline. Results: Out of 321 registered patients, 261 were included in the study: 139 women (53.3%), median age at RA-ILD diagnosis 65 years (interquartile range [IQR] 57 to 71), 151 ever smokers (59.2%). Median follow-up was 3.5 years (IQR 1.3 to 6.6). Mortality rate was 32% (95%CI 19 to 42) at 10 years. The MUC5B rs35705950 variant did not impact lung transplant-free survival (HR for the T risk allele carriers=1.26; 95%CI 0.61 to 2.62; P=0.53). Decline in pulmonary function at 2 years was not influenced by MUC5B rs35705950 (OR=0.95; 95%CI 0.44 to 2.05; P=0.89), irrespective of the HRCT pattern. Conclusion: In this study, the MUC5B rs35705950 promoter variant did not influence transplant- free survival or decline in pulmonary function in patients with RA-ILD.
dc.language.isoENen_US
dc.subject.enGenetics
dc.subject.enInterstitial Lung Disease
dc.subject.enMUC5B
dc.subject.enRheumatoid Arthritis
dc.title.enMUC5B promoter variant rs35705950 and rheumatoid arthritis associated interstitial lung disease survival and progression
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.semarthrit.2021.07.002en_US
dc.subject.halSciences du Vivant [q-bio]/Immunologieen_US
dc.identifier.pubmed34411838en_US
bordeaux.journalSeminars in Arthritis and Rheumatismen_US
bordeaux.page996-1004en_US
bordeaux.volume51en_US
bordeaux.hal.laboratoriesImmunoConcEpT - UMR 5164en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionCNRSen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03656353
hal.version1
hal.date.transferred2022-05-02T08:07:42Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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