Towards an approach of disability along a continuum from robustness, pre-frailty, frailty to disability
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | ZAMUDIO RODRIGUEZ, Alfonso | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AVILA-FUNES, Jose Alberto | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | TABUE TEGUO, Maturin
ORCID: 0000-0002-1211-5660 IDREF: 175400768 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DARTIGUES, Jean-Francois
ORCID: 0000-0001-9482-5529 IDREF: 058586105 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AMIEVA, Helene | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PERES, Karine | |
| dc.date.accessioned | 2022-04-28T10:53:44Z | |
| dc.date.available | 2022-04-28T10:53:44Z | |
| dc.date.issued | 2022-03-01 | |
| dc.identifier.issn | 1468-2834 (Electronic) 0002-0729 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139942 | |
| dc.description.abstractEn | BACKGROUND: frailty and disability are very prevalent in older age and although both are distinct clinical entities, they are commonly used indistinctly in order to identify vulnerable older adults. OBJECTIVE: to propose a hierarchical indicator between frailty and disability among older adults along a single continuum. DESIGN: population-based cohort study. SETTING: the Bordeaux Three-City Study and the Aging Multidisciplinary Investigation (AMI) cohort. SUBJECTS: the sample included 1800 participants aged 65 and older. METHODS: an additive hierarchical indicator was proposed by combining the phenotype of frailty (robustness, pre-frailty and frailty), instrumental activities of daily living (IADL) and basic activities of daily living (ADL). To test the relevance of this indicator, we estimated the 4-year mortality risk associated with each stage of the indicator. RESULTS: in total, 34.0% were Robust (n = 612), 29.9% were Pre-frail (n = 538), 3.2% were Robust with IADL-disability (n = 58), 4.6% had pure Frailty (no disability) (n = 82), 11.9% were Pre-frail + IADL (n = 215), 8.6% were Frail + IADL (n = 154) and 7.8% Frail + IADL + ADL (n = 141). After grouping grades with similar mortality risks, we obtained a five-grade hierarchical indicator ranging from robustness to severe stage of the continuum. Each state presented a gradually increasing risk of dying compared to the robust group (from Hazard Ratio (HR) = 2.20 [1.49-3.25] to 15.10 [9.99-22.82]). CONCLUSIONS: We confirmed that combining pre-frailty, frailty, IADL- and ADL-disability into a single indicator may improve our understanding of the aging process. Pre-frailty identified as the 'entry door' into the process may represent a key stage that could offer new opportunities for early, targeted, individualized and tailored interventions and care in clinical geriatrics. | |
| dc.description.sponsorship | COGINUT : Cognition, anti-oxydants, acides gras: approche interdisciplinaire du rôle de la nutrition dans le vieillissement du cerveau - ANR-06-PNRA-0005 | en_US |
| dc.description.sponsorship | Histoire naturelle du déclin cognitif et du besoin de soins chez le sujet âgé | en_US |
| dc.language.iso | EN | en_US |
| dc.subject.en | Frailty | |
| dc.subject.en | Activities of daily living | |
| dc.subject.en | Hierarchical process | |
| dc.subject.en | Mortality | |
| dc.subject.en | Older people | |
| dc.title.en | Towards an approach of disability along a continuum from robustness, pre-frailty, frailty to disability | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1093/ageing/afac025 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35231091 | en_US |
| bordeaux.journal | Age and Ageing | en_US |
| bordeaux.volume | 51 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 3 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | ACTIVE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Institut National de la Santé et de la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Fondation pour la Recherche Médicale | en_US |
| bordeaux.identifier.funderID | Mutuelle Générale de l'Education Nationale | en_US |
| bordeaux.identifier.funderID | Conseil Régional Aquitaine | en_US |
| bordeaux.identifier.funderID | Conseil régional de Bourgogne-Franche-Comté | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement supérieur, de la Recherche et de l'Innovation | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| bordeaux.identifier.funderID | Caisse nationale de solidarité pour l'autonomie | en_US |
| bordeaux.identifier.funderID | Mutualité Sociale Agricole | en_US |
| bordeaux.identifier.funderID | Caisse Centrale de la Mutualité Sociale Agricole | en_US |
| hal.identifier | hal-03654086 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-04-28T10:53:47Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Age%20and%20Ageing&rft.date=2022-03-01&rft.volume=51&rft.issue=3&rft.eissn=1468-2834%20(Electronic)%200002-0729%20(Linking)&rft.issn=1468-2834%20(Electronic)%200002-0729%20(Linking)&rft.au=ZAMUDIO%20RODRIGUEZ,%20Alfonso&AVILA-FUNES,%20Jose%20Alberto&TABUE%20TEGUO,%20Maturin&DARTIGUES,%20Jean-Francois&AMIEVA,%20Helene&rft.genre=article |
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