Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients
| dc.rights.license | open | en_US |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | PREVEL, Renaud | |
| dc.contributor.author | DUPONT, Annabelle | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | LABROUCHE-COLOMER, Sylvie | |
| dc.contributor.author | GARCIA, GEOFFREY | |
| hal.structure.identifier | Immunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept] | |
| dc.contributor.author | DEWITTE, Antoine | |
| dc.contributor.author | RAUCH, ANTOINE | |
| dc.contributor.author | GOUTAY, JULIEN | |
| dc.contributor.author | CAPLAN, MORGAN | |
| dc.contributor.author | JOZEFOWICZ, Elsa | |
| dc.contributor.author | LANOIX, JEAN-PHILIPPE | |
| dc.contributor.author | POISSY, Julien | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | RIVIERE, Etienne | |
| dc.contributor.author | ORIEUX, Arthur | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| hal.structure.identifier | Global Health in the Global South [GHiGS] | |
| dc.contributor.author | MALVY, Denis | |
| hal.structure.identifier | Microbiologie Fondamentale et Pathogénicité [MFP] | |
| dc.contributor.author | GRUSON, Didier | |
| dc.contributor.author | GARCON, LOIC | |
| dc.contributor.author | SUSEN, Sophie | |
| hal.structure.identifier | Biologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases | |
| dc.contributor.author | JAMES, Chloe | |
| dc.date.accessioned | 2022-04-20T08:37:56Z | |
| dc.date.available | 2022-04-20T08:37:56Z | |
| dc.date.issued | 2022-03-17 | |
| dc.identifier.issn | 1664-3224 (Electronic) 1664-3224 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/139870 | |
| dc.description.abstractEn | INTRODUCTION: Coronavirus disease 2019 (COVID-19) can cause life-threatening acute respiratory distress syndrome (ARDS). Recent data suggest a role for neutrophil extracellular traps (NETs) in COVID-19-related lung damage partly due to microthrombus formation. Besides, pulmonary embolism (PE) is frequent in severe COVID-19 patients, suggesting that immunothrombosis could also be responsible for increased PE occurrence in these patients. Here, we evaluate whether plasma levels of NET markers measured shorty after admission of hospitalized COVID-19 patients are associated with clinical outcomes in terms of clinical worsening, survival, and PE occurrence. PATIENTS AND METHODS: Ninety-six hospitalized COVID-19 patients were included, 50 with ARDS (severe disease) and 46 with moderate disease. We collected plasma early after admission and measured 3 NET markers: total DNA, myeloperoxidase (MPO)-DNA complexes, and citrullinated histone H3. Comparisons between survivors and non-survivors and patients developing PE and those not developing PE were assessed by Mann-Whitney test. RESULTS: Analysis in the whole population of hospitalized COVID-19 patients revealed increased circulating biomarkers of NETs in patients who will die from COVID-19 and in patients who will subsequently develop PE. Restriction of our analysis in the most severe patients, i.e., the ones who enter the hospital for COVID-19-related ARDS, confirmed the link between NET biomarker levels and survival but not PE occurrence. CONCLUSION: Our results strongly reinforce the hypothesis that NETosis is an attractive therapeutic target to prevent COVID-19 progression but that it does not seem to be linked to PE occurrence in patients hospitalized with COVID-19. | |
| dc.description.sponsorship | Role de l'équilibre NET/ DNase dans la gravité de la COVID-19 | en_US |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | Neutrophil extracellular trap | |
| dc.subject.en | Acute respiratory distress syndrome | |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Immunothrombosis | |
| dc.subject.en | Pulmonary embolism | |
| dc.title.en | Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3389/fimmu.2022.851497 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35371025 | en_US |
| bordeaux.journal | Frontiers in Immunology | en_US |
| bordeaux.volume | 13 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.institution | CNRS | |
| bordeaux.team | GHIGS_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Université de Bordeaux | en_US |
| bordeaux.identifier.funderID | Agence Nationale de la Recherche | en_US |
| hal.identifier | hal-03626002 | |
| hal.version | 1 | |
| hal.export | false | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Immunology&rft.date=2022-03-17&rft.volume=13&rft.eissn=1664-3224%20(Electronic)%201664-3224%20(Linking)&rft.issn=1664-3224%20(Electronic)%201664-3224%20(Linking)&rft.au=PREVEL,%20Renaud&DUPONT,%20Annabelle&LABROUCHE-COLOMER,%20Sylvie&GARCIA,%20GEOFFREY&DEWITTE,%20Antoine&rft.genre=article |
