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Plasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients

dc.rights.licenseopenen_US
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorPREVEL, Renaud
dc.contributor.authorDUPONT, Annabelle
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorLABROUCHE-COLOMER, Sylvie
dc.contributor.authorGARCIA, GEOFFREY
hal.structure.identifierImmunology from Concept and Experiments to Translation = Immunologie Conceptuelle, Expérimentale et Translationnelle [ImmunoConcept]
dc.contributor.authorDEWITTE, Antoine
dc.contributor.authorRAUCH, ANTOINE
dc.contributor.authorGOUTAY, JULIEN
dc.contributor.authorCAPLAN, MORGAN
dc.contributor.authorJOZEFOWICZ, Elsa
dc.contributor.authorLANOIX, JEAN-PHILIPPE
dc.contributor.authorPOISSY, Julien
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorRIVIERE, Etienne
dc.contributor.authorORIEUX, Arthur
hal.structure.identifierBordeaux population health [BPH]
hal.structure.identifierGlobal Health in the Global South [GHiGS]
dc.contributor.authorMALVY, Denis
ORCID: 0000-0003-1948-9355
IDREF: 148480993
hal.structure.identifierMicrobiologie Fondamentale et Pathogénicité [MFP]
dc.contributor.authorGRUSON, Didier
dc.contributor.authorGARCON, LOIC
dc.contributor.authorSUSEN, Sophie
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorJAMES, Chloe
dc.date.accessioned2022-04-20T08:37:56Z
dc.date.available2022-04-20T08:37:56Z
dc.date.issued2022-03-17
dc.identifier.issn1664-3224 (Electronic) 1664-3224 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/139870
dc.description.abstractEnINTRODUCTION: Coronavirus disease 2019 (COVID-19) can cause life-threatening acute respiratory distress syndrome (ARDS). Recent data suggest a role for neutrophil extracellular traps (NETs) in COVID-19-related lung damage partly due to microthrombus formation. Besides, pulmonary embolism (PE) is frequent in severe COVID-19 patients, suggesting that immunothrombosis could also be responsible for increased PE occurrence in these patients. Here, we evaluate whether plasma levels of NET markers measured shorty after admission of hospitalized COVID-19 patients are associated with clinical outcomes in terms of clinical worsening, survival, and PE occurrence. PATIENTS AND METHODS: Ninety-six hospitalized COVID-19 patients were included, 50 with ARDS (severe disease) and 46 with moderate disease. We collected plasma early after admission and measured 3 NET markers: total DNA, myeloperoxidase (MPO)-DNA complexes, and citrullinated histone H3. Comparisons between survivors and non-survivors and patients developing PE and those not developing PE were assessed by Mann-Whitney test. RESULTS: Analysis in the whole population of hospitalized COVID-19 patients revealed increased circulating biomarkers of NETs in patients who will die from COVID-19 and in patients who will subsequently develop PE. Restriction of our analysis in the most severe patients, i.e., the ones who enter the hospital for COVID-19-related ARDS, confirmed the link between NET biomarker levels and survival but not PE occurrence. CONCLUSION: Our results strongly reinforce the hypothesis that NETosis is an attractive therapeutic target to prevent COVID-19 progression but that it does not seem to be linked to PE occurrence in patients hospitalized with COVID-19.
dc.description.sponsorshipRole de l'équilibre NET/ DNase dans la gravité de la COVID-19 - ANR-21-CO12-0006en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enNeutrophil extracellular trap
dc.subject.enAcute respiratory distress syndrome
dc.subject.enCOVID-19
dc.subject.enImmunothrombosis
dc.subject.enPulmonary embolism
dc.title.enPlasma Markers of Neutrophil Extracellular Trap Are Linked to Survival but Not to Pulmonary Embolism in COVID-19-Related ARDS Patients
dc.typeArticle de revueen_US
dc.identifier.doi10.3389/fimmu.2022.851497en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35371025en_US
bordeaux.journalFrontiers in Immunologyen_US
bordeaux.volume13en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamGHIGS_BPHen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.identifierhal-03626002
hal.version1
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Frontiers%20in%20Immunology&rft.date=2022-03-17&rft.volume=13&rft.eissn=1664-3224%20(Electronic)%201664-3224%20(Linking)&rft.issn=1664-3224%20(Electronic)%201664-3224%20(Linking)&rft.au=PREVEL,%20Renaud&DUPONT,%20Annabelle&LABROUCHE-COLOMER,%20Sylvie&GARCIA,%20GEOFFREY&DEWITTE,%20Antoine&rft.genre=article


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