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hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorINCERTI, S.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorSEZNEC, H.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorSIMON, M.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorBARBERET, Ph.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
hal.structure.identifierUniversité Sciences et Technologies - Bordeaux 1 [UB]
dc.contributor.authorMORETTO, P.
dc.date.issued2009-01
dc.identifier.issn0144-8420
dc.description.abstractEnMicrobeam facilities provide a unique opportunity to investigate the effects of ionising radiation on living biological cells with a precise control of the delivered dose. This paper describes dosimetry calculations performed at the single-cell level in the microbeam irradiation facility available at the Centre d'Etudes Nucleaires de Bordeaux-Gradignan in France, using the object-oriented Geant4 Monte Carlo simulation toolkit. The cell geometry model is based on high-resolution three-dimensional voxelised phantoms of a human keratinocyte (HaCaT) cell line. Such phantoms are built from confocal microscopy imaging and from ion beam chemical elemental analysis. Results are presented for single-cell irradiation with 3 MeV incident alpha particles.
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.subject.enCELLULAR IRRADIATION
dc.subject.enSIMULATION TOOLKIT
dc.subject.enCENBG MICROBEAM
dc.subject.enGEANT4
dc.subject.enLINE
dc.subject.enSOFTWARE
dc.subject.enPROTEIN
dc.subject.enDESIGN
dc.title.enMonte Carlo dosimetry for targeted irradiation of individual cells using a microbeam facility
dc.typeArticle de revue
dc.identifier.doi10.1093/rpd/ncp003
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
dc.subject.halPhysique [physics]/Physique [physics]/Instrumentations et Détecteurs [physics.ins-det]
bordeaux.journalRadiation Protection Dosimetry
bordeaux.page2-11
bordeaux.volume133
bordeaux.peerReviewedoui
hal.identifierin2p3-00373963
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//in2p3-00373963v1
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