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Investigation of neutron radiation effects on polyclonal antibodies (IgG) and fluorescein dye for astrobiology applications

hal.structure.identifierLaboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux [L3AB]
hal.structure.identifierObservatoire aquitain des sciences de l'univers [OASU]
hal.structure.identifierLaboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]
dc.contributor.authorLE POSTOLLEC, A.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorCOUSSOT, G.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorBAQUÉ, M.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, S.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorDESVIGNES, I.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMORETTO, P.
hal.structure.identifierLaboratoire d'astrodynamique, d'astrophysique et d'aéronomie de bordeaux [L3AB]
hal.structure.identifierObservatoire aquitain des sciences de l'univers [OASU]
hal.structure.identifierLaboratoire d'Astrophysique de Bordeaux [Pessac] [LAB]
dc.contributor.authorDOBRIJEVIC, M.
hal.structure.identifierInstitut des Biomolécules Max Mousseron [Pôle Chimie Balard] [IBMM]
dc.contributor.authorVANDENABEELE-TRAMBOUZE, O.
dc.date.issued2009
dc.identifier.issn1531-1074
dc.description.abstractEnDetecting life in the Solar System is one of the great challenges of new upcoming space missions. Biochips have been proposed as a way to detect organic matter on extraterrestrial objects. A biochip is a miniaturized device composed of biologically sensitive systems, such as antibodies, which are immobilized on a slide. In the case of in situ measurements, the main concern is to ensure the survival of the antibodies under space radiation. Our recent computing simulation of cosmic ray interactions with the martian environment shows that neutrons are one of the dominant species at soil level. Therefore, we have chosen, in a first approach, to study antibody resistance to neutrons by performing irradiation experiments at the Applications Interdisciplinaires des Faisceaux d'Ions en Region Aquitaine (AIFIRA) platform, a French ion beam facility at the Centre d'Etudes Nucleaires de Bordeaux-Gradignan in Bordeaux. Antibodies and fluorescent dyes, freeze-dried and in buffer solution, were irradiated with 0.6 MeV and 6 MeV neutrons. Sample analyses demonstrated that, in the conditions tested, antibody recognition capability and fluorescence dye intensity are not affected by the neutrons.
dc.language.isoen
dc.publisherMary Ann Liebert
dc.subjectIrradiation
dc.subjectNeutrons
dc.subjectAntibodies
dc.subjectFluorescent dyes
dc.title.enInvestigation of neutron radiation effects on polyclonal antibodies (IgG) and fluorescein dye for astrobiology applications
dc.typeArticle de revue
dc.identifier.doi10.1089/ast.2008.0303
dc.subject.halPlanète et Univers [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
dc.subject.halPhysique [physics]/Astrophysique [astro-ph]/Planétologie et astrophysique de la terre [astro-ph.EP]
bordeaux.journalAstrobiology
bordeaux.page637-645
bordeaux.volume9
bordeaux.peerReviewedoui
hal.identifierhal-00429221
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00429221v1
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