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Energy deposition in small-scale targets of liquid water using the very low energy electromagnetic physics processes of the Geant4 toolkit

hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorINCERTI, S.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorCHAMPION, C.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorTRAN, H.N.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorKARAMITROS, M.
dc.contributor.authorBERNAL, M.
dc.contributor.authorFRANCIS, Z.
hal.structure.identifierInterface Physique et Chimie pour le Vivant [IPCV]
dc.contributor.authorIVANCHENKO, V.
dc.contributor.authorMANTERO, A.
dc.date.issued2013
dc.identifier.issn0168-583X
dc.description.abstractEnIn the perspective of building an open source simulation platform dedicated to the modelling of early biological molecular damages due to ionising radiation at the DNA scale, the general-purpose Geant4 Monte Carlo simulation toolkit has been recently extended with specific very low energy electromagnetic physics processes for liquid water medium. These processes - also called ''Geant4-DNA'' processes - simulate the physical interactions induced by electrons, hydrogen and helium atoms of different charge states. The present work reports on the energy deposit distributions obtained for incident electrons, protons and alpha particles in nanometre-size volumes comparable to those present in the genetic material of mammalian cells. The frequency distributions of the energy deposition obtained for three typical geometries of nanometre-size cylindrical targets placed in a spherical phantom are found to be in reasonable agreement with prior works. Furthermore, we present a combination of the Geant4-DNA processes with a simplified geometrical model of a cellular nucleus allowing the evaluation of energy deposits in volumes of biological interest.
dc.language.isoen
dc.publisherElsevier
dc.subject.enMonte Carlo Geant4 Geant4-DNA Microdosimetry Electromagnetic interactions
dc.title.enEnergy deposition in small-scale targets of liquid water using the very low energy electromagnetic physics processes of the Geant4 toolkit
dc.typeArticle de revue
dc.identifier.doi10.1016/j.nimb.2012.12.054
dc.subject.halPhysique [physics]/Physique [physics]/Biophysique [physics.bio-ph]
bordeaux.journalNuclear Instruments and Methods in Physics Research Section B: Beam Interactions with Materials and Atoms
bordeaux.page158-164
bordeaux.volume306
bordeaux.peerReviewedoui
hal.identifierin2p3-00835917
hal.version1
hal.popularnon
hal.audienceNon spécifiée
hal.origin.linkhttps://hal.archives-ouvertes.fr//in2p3-00835917v1
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