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Cell micro-irradiation with MeV protons counted by an ultra-thin diamond membrane

hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorBARBERET, Philippe
hal.structure.identifierLaboratoire Capteurs Diamant (CEA, LIST) [LCD (CEA, LIST)]
dc.contributor.authorPOMORSKI, Michal
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorMUGGIOLU, Giovanna
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorTORFEH, Eva
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorCLAVERIE, Gérard
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorHUSS, Cédric
hal.structure.identifierLaboratoire Capteurs Diamant (CEA, LIST) [LCD (CEA, LIST)]
dc.contributor.authorSAADA, Samuel
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorDEVÈS, Guillaume
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSIMON, Marina
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSEZNEC, Hervé
dc.date.issued2017-12-11
dc.identifier.issn0003-6951
dc.description.abstractEnWe report the development of thin single crystal diamond membranes suitable for dose control in targeted cell irradiation experiments with a proton microbeam. A specific design was achieved to deliver single protons with a hit detection efficiency approaching 100%. The membranes have thicknesses between 1.8 and 3 pm and arc used as vacuum windows on the microbeam line. The impact of these transmission detectors on the microbeam spot size is estimated by Monte-Carlo simulations, indicating that a beam lateral resolution below 2 µm is achieved. This is confirmed by experiments showing the accumulation online of X-ray Repair Cross-Complementing protein 1 (XRCC1)-Green Fluorescent Protein (GFP) at DNA damaged sites in living cells.
dc.language.isoen
dc.publisherAmerican Institute of Physics
dc.subject.enCHARGED-PARTICLE MICROBEAM
dc.subject.enSINGLE
dc.subject.enREPAIR
dc.subject.enRECRUITMENT
dc.title.enCell micro-irradiation with MeV protons counted by an ultra-thin diamond membrane
dc.typeArticle de revue
dc.identifier.doi10.1063/1.5009713
dc.subject.halSciences de l'ingénieur [physics]/Micro et nanotechnologies/Microélectronique
dc.subject.halPhysique [physics]/Physique [physics]/Instrumentations et Détecteurs [physics.ins-det]
dc.subject.halPhysique [physics]/Physique Nucléaire Expérimentale [nucl-ex]
dc.subject.halInformatique [cs]/Modélisation et simulation
dc.description.sponsorshipEuropeSupport of Public and Industrial Research using Ion Beam Technology
dc.description.sponsorshipEuropeSupporting Postgraduate Research with Internships in industry and Training Excellence
bordeaux.journalApplied Physics Letters
bordeaux.page243701
bordeaux.volume111
bordeaux.issue24
bordeaux.peerReviewedoui
hal.identifiercea-01874782
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//cea-01874782v1
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Applied%20Physics%20Letters&rft.date=2017-12-11&rft.volume=111&rft.issue=24&rft.spage=243701&rft.epage=243701&rft.eissn=0003-6951&rft.issn=0003-6951&rft.au=BARBERET,%20Philippe&POMORSKI,%20Michal&MUGGIOLU,%20Giovanna&TORFEH,%20Eva&CLAVERIE,%20G%C3%A9rard&rft.genre=article


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