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Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models

dc.contributor.authorENGELS, Elette
dc.contributor.authorBAKR, Samer
dc.contributor.authorBOLST, David
dc.contributor.authorSAKATA, Dousatsu
dc.contributor.authorLI, Nan
dc.contributor.authorLAZARAKIS, Peter
dc.contributor.authorMCMAHON, Stephen
dc.contributor.authorIVANCHENKO, Vladimir
dc.contributor.authorROSENFELD, Anatoly
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorINCERTI, Sébastien
dc.contributor.authorKYRIAKOU, Ioanna
dc.contributor.authorEMFIETZOGLOU, Dimitris
dc.contributor.authorLERCH, Michael
dc.contributor.authorTEHEI, Moeava
dc.contributor.authorCORDE, Stéphanie
dc.contributor.authorGUATELLI, Susanna
dc.date.issued2020-09-11
dc.identifier.issn0031-9155
dc.description.abstractEnGold nanoparticles have demonstrated significant radiosensitization of cancer treatment with X-ray radiotherapy. To understand the mechanisms at the basis of nanoparticle radiosensitization, Monte Carlo simulations are used to investigate the dose enhancement, given a certain nanoparticle concentration and distribution in the biological medium. Earlier studies have ordinarily used condensed history physics models to predict nanoscale dose enhancement with nanoparticles. This study uses Geant4-DNA complemented with novel track structure physics models to accurately describe electron interactions in gold and to calculate the dose surrounding gold nanoparticle structures at nanoscale level. The computed dose in silico due to a clinical kilovoltage beam in presence of gold nanoparticles was related to in vitro brain cancer cell survival using the Local Effect Model. The comparison of the simulation results with radiobiological experimental measurements shows that Geant4-DNA and Local Effect Model can be used to predict cell survival in silico in the case of X-ray kilovoltage beams
dc.language.isoen
dc.publisherIOP Publishing
dc.subject.enGeant4
dc.subject.enGeant4-DNA
dc.subject.enGold Nanoparticles
dc.subject.enDose Enhancement
dc.subject.enCell Survival
dc.subject.enLocal Effect Model
dc.title.enAdvances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models
dc.typeArticle de revue
dc.identifier.doi10.1088/1361-6560/abb7c2
dc.subject.halPhysique [physics]/Physique [physics]/Physique Médicale [physics.med-ph]
bordeaux.journalPhysics in Medicine and Biology
bordeaux.page225017
bordeaux.volume65
bordeaux.peerReviewedoui
hal.identifierhal-02988406
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-02988406v1
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