ENGELS, Elette; BAKR, Samer; BOLST, David; SAKATA, Dousatsu; LI, Nan; LAZARAKIS, Peter; MCMAHON, Stephen; IVANCHENKO, Vladimir; ROSENFELD, Anatoly; INCERTI, Sébastien; KYRIAKOU, Ioanna; EMFIETZOGLOU, Dimitris; LERCH, Michael; TEHEI, Moeava; CORDE, Stéphanie; GUATELLI, Susanna

doi:10.1088/1361-6560/abb7c2

Métadonnées

Afficher la notice complète

Licence d’utilisation du document

Langue

Article de revue

Ce document a été publié dans

Physics in Medicine and Biology. 2020-09-11, vol. 65, p. 225017

IOP Publishing

Résumé en anglais

Gold nanoparticles have demonstrated significant radiosensitization of cancer treatment with X-ray radiotherapy. To understand the mechanisms at the basis of nanoparticle radiosensitization, Monte Carlo simulations are used to investigate the dose enhancement, given a certain nanoparticle concentration and distribution in the biological medium. Earlier studies have ordinarily used condensed history physics models to predict nanoscale dose enhancement with nanoparticles. This study uses Geant4-DNA complemented with novel track structure physics models to accurately describe electron interactions in gold and to calculate the dose surrounding gold nanoparticle structures at nanoscale level. The computed dose in silico due to a clinical kilovoltage beam in presence of gold nanoparticles was related to in vitro brain cancer cell survival using the Local Effect Model. The comparison of the simulation results with radiobiological experimental measurements shows that Geant4-DNA and Local Effect Model can be used to predict cell survival in silico in the case of X-ray kilovoltage beams< Réduire

Mots clés en anglais

Geant4

Geant4-DNA

Gold Nanoparticles

Dose Enhancement

Cell Survival

Local Effect Model

Métadonnées

Licence d’utilisation du document

Advances in modelling gold nanoparticle radiosensitization using new Geant4-DNA physics models

Langue

Ce document a été publié dans

Résumé en anglais

Mots clés en anglais

DOI

Origine

Unités de recherche