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hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorBARBERET, P.
hal.structure.identifierCentre d'Etudes Nucléaires de Bordeaux Gradignan [CENBG]
dc.contributor.authorSEZNEC, H.
dc.date.issued2015-09-14
dc.identifier.issn0144-8420
dc.description.abstractEnCharged-particle microbeams (CPMs) allow the targeting of sub-cellular compartments with a counted number of energetic ions. While initially developed in the late 1990s to overcome the statistical fluctuation on the number of traversals per cell inevitably associated with broad beam irradiations, CPMs have generated a growing interest and are now used in a wide range of radiation biology studies. Besides the study of the low-dose cellular response that has prevailed in the applications of these facilities for many years, several new topics have appeared recently. By combining their ability to generate highly clustered damages in a micrometric volume with immunostaining or live-cell GFP labelling, a huge potential for monitoring radiation-induced DNA damage and repair has been introduced. This type of studies has pushed end-stations towards advanced fluorescence microscopy techniques, and several microbeam lines are currently equipped with the state-of-the-art time-lapse fluorescence imaging microscopes. In addition, CPMs are nowadays also used to irradiate multicellular models in a highly controlled way. This review presents the latest developments and applications of charged-particle microbeams to radiation biology
dc.language.isoen
dc.publisherOxford University Press (OUP)
dc.title.enAdvances in microbeam technologies and applications to radiation biology: Table 1.
dc.typeArticle de revue
dc.identifier.doi10.1093/rpd/ncv192
dc.subject.halPhysique [physics]
bordeaux.journalRadiation Protection Dosimetry
bordeaux.page182-187
bordeaux.volume166
bordeaux.issue1-4
bordeaux.peerReviewedoui
hal.identifierhal-03127129
hal.version1
hal.popularnon
hal.audienceInternationale
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-03127129v1
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