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dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCATHALA, Adeline
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSPAMPINATO, Umberto
dc.contributor.editorSPRINGER
dc.date.accessioned2022-04-04T13:05:38Z
dc.date.available2022-04-04T13:05:38Z
dc.date.issued2021
dc.identifier.isbn978-3-030-55920-5en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136594
dc.description.abstractEnThe serotonin 2B receptor (5-HT2BR) is the most recent addition to the 5-HT2R family. During the last decade, a growing number of studies have shown that the central 5-HT2BR participates in the control of serotonin (5-HT) and dopamine (DA) neuron activity and have underlined its potential for new therapeutic strategies for several neuropsychiatric disorders such as drug addiction, depression and schizophrenia. After reviewing the major advances in the identification and characterization of this receptor within the central nervous system, this chapter focuses on its functional role in the control of ascending DA pathway activity and on the mechanisms underlying this interaction, by covering electrophysiological, neurochemical and behavioral data mainly from in vivo studies in rats. Afterwards, the therapeutic relevance of 5-HT2BR antagonists for treating DA-dependent neuropsychiatric disorders is discussed by focusing on schizophrenia.
dc.language.isoENen_US
dc.publisherSpringeren_US
dc.publisher.locationChamen_US
dc.source.title5-HT2B Receptors: from Molecular Biology to Clinical Applicationsen_US
dc.subject.enDopamine
dc.subject.enDorsal raphe nucleus
dc.subject.enIntracerebral microdialysis
dc.subject.enMedial prefrontal cortex
dc.subject.enNucleus accumbens
dc.subject.enRat
dc.subject.enSchizophrenia
dc.subject.enSerotonin
dc.subject.enSerotonin 2B receptor
dc.title.enSerotonin 2B Receptor Interactions with Dopamine Network: Implications for Therapeutics in Schizophrenia
dc.typeChapitre d'ouvrageen_US
dc.identifier.doi10.1007/978-3-030-55920-5_19en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.page323-333en_US
bordeaux.volume35en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Santé et de la Recherche Médicaleen_US
bordeaux.identifier.funderIDUniversité de Bordeauxen_US
hal.identifierhal-03629706
hal.version1
hal.date.transferred2022-04-04T13:05:40Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.btitle=5-HT2B%20Receptors:%20from%20Molecular%20Biology%20to%20Clinical%20Applications&rft.date=2021&rft.volume=35&rft.spage=323-333&rft.epage=323-333&rft.au=CATHALA,%20Adeline&SPAMPINATO,%20Umberto&rft.isbn=978-3-030-55920-5&rft.genre=unknown


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