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dc.rights.licenseopenen_US
dc.contributor.authorCAMBOS, Sophie
dc.contributor.authorCHANSON, Philippe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTABARIN, Antoine
dc.date.accessioned2022-03-25T13:05:39Z
dc.date.available2022-03-25T13:05:39Z
dc.date.issued2021-02
dc.identifier.issn0003-4266en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136539
dc.description.abstractEnThe assay of multiple steroids by mass spectrometry coupled with chromatography, combined with data analysis using an artificial intelligence approach, has become more widely accessible in recent years. Multiple applications for this technology exist for the study of adrenocortical tumors. Taking advantage of the capacity of malignant cortical tumor secretion of non-bioactive precursors, it provides an additional diagnostic approach that can point to the nature of a tumor. These encouraging perspectives have been based to date only on pilot retrospective studies. However, this has changed in 2020 with the publication of data from the EURINE-ACT study. This very large prospective European study provided more nuanced evidence for the benefit of combining the measurement of a panel of steroids with essential imaging tools. This study also facilitated our understanding and provided more precise characterisation of autonomous steroid secretion, particularly in the case of sublinical cortisol-secreting adrenocortical adenomas. This article will focus on our current knowledge on the potential utility of mass spectrometry for diagnosis of both the nature of an adrenal tumors and their secretion.
dc.language.isoENen_US
dc.subject.enAdrenal steroids
dc.subject.enAdrenal tumors
dc.subject.enAdrenocortical carcinoma
dc.subject.enAutonomous cortisol secreting adenoma
dc.subject.enMachine learning
dc.subject.enMass spectrometry
dc.title.enAnalysis of steroid profiles by mass spectrometry: A new tool for exploring adrenal tumors?
dc.title.alternativeAnn Endocrinolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.ando.2020.12.001en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33278379en_US
bordeaux.journalAnnales d'Endocrinologieen_US
bordeaux.page36-42en_US
bordeaux.volume82en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03619932
hal.version1
hal.date.transferred2022-03-25T13:05:40Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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