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Characterization of Kisspeptin Neurons in the Human Rostral Hypothalamus

dc.rights.licenseopenen_US
dc.contributor.authorRUMPLER, E.
dc.contributor.authorSKRAPITS, K.
dc.contributor.authorTAKACS, S.
dc.contributor.authorGOCZ, B.
dc.contributor.authorTRINH, S.H.
dc.contributor.authorRACZ, G.
dc.contributor.authorMATOLCSY, A.
dc.contributor.authorKOZMA, Z.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCIOFI, Philippe
dc.contributor.authorDHILLO, W.S.
dc.contributor.authorHRABOVSZKY, E.
dc.date.accessioned2022-03-24T11:49:32Z
dc.date.available2022-03-24T11:49:32Z
dc.date.issued2021
dc.identifier.issn0028-3835 1423-0194en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136524
dc.description.abstractEnBackground: Kisspeptin (KP) neurons in the rostral periventricular region of the 3rd ventricle (RP3V) of female rodents mediate positive estrogen feedback to gonadotropin-releasing hormone neurons and, thus, play a fundamental role in the mid-cycle luteinizing hormone (LH) surge. The RP3V is sexually dimorphic, and male rodents with lower KP cell numbers are unable to mount estrogen-induced LH surges. Objective: To find and characterize the homologous KP neurons in the human brain, we studied formalin-fixed post-mortem hypothalami. Methods: Immunohistochemical techniques were used. Results: The distribution of KP neurons in the rostral hypothalamus overlapped with distinct subdivisions of the paraventricular nucleus. The cell numbers decreased after menopause, indicating that estrogens positively regulate KP gene expression in the rostral hypothalamus in humans, similarly to several other species. Young adult women and men had similar cell numbers, as opposed to rodents reported to have more KP neurons in the RP3V of females. Human KP neurons differed from the homologous rodent cells as well, in that they were devoid of enkephalins, galanin and tyrosine hydroxylase. Further, they did not contain known KP neuron markers of the human infundibular nucleus, neurokinin B, substance P and cocaine- A nd amphetamine-regulated transcript, while they received afferent input from these KP neurons. Conclusions: The identification and positive estrogenic regulation of KP neurons in the human rostral hypothalamus challenge the long-held view that positive estrogen feedback may be restricted to the mediobasal part of the hypothalamus in primates and point to the need of further anatomical, molecular and functional studies of rostral hypothalamic KP neurons.
dc.language.isoENen_US
dc.subject.enGonadotropin-releasing hormone
dc.subject.enImmunohistochemistry
dc.subject.enPositive feedback
dc.subject.enReproduction
dc.title.enCharacterization of Kisspeptin Neurons in the Human Rostral Hypothalamus
dc.typeArticle de revueen_US
dc.identifier.doi10.1159/000507891en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed32299085en_US
bordeaux.journalNeuroendocrinologyen_US
bordeaux.page249-262en_US
bordeaux.volume111en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue3en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03618465
hal.version1
hal.date.transferred2022-03-24T11:49:36Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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