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dc.rights.licenseopenen_US
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLASSELIN, Julie
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorLAYE, Sophie
ORCID: 0000-0002-3843-1012
IDREF: 11366883X
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDEXPERT, Sandra
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorAUBERT, Agnes
dc.contributor.authorGONZALEZ, Concepcion
dc.contributor.authorGIN, Henri
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
dc.date.accessioned2022-03-24T09:41:35Z
dc.date.available2022-03-24T09:41:35Z
dc.date.issued2012-11-01
dc.identifier.issn1090-2139en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136522
dc.description.abstractEnFatigue is frequent in patients with diabetes and this symptom appears to be more prominent in type 2 rather than type 1 diabetic subjects. Chronic inflammation represents one characteristic of type 2 diabetes that may contribute to fatigue symptoms. This possibility was assessed in a sample of 20 type 2 diabetic patients relatively to a group of 20 type 1 diabetic subjects. Specific dimensions of fatigue, including general fatigue, physical fatigue, reduced activity, mental fatigue and reduced motivation, were assessed using the Multidimensional-Fatigue-Inventory (MFI). Biological assays comprised the measurement of serum inflammatory markers [high-sensitive C-reactive-protein (hsCRP), high-sensitive interleukin-6 (hsIL-6), high-sensitive tumor-necrosis-factor-α (hsTNF-α) and neopterin]. Clinical parameters including indexes of adiposity were collected. In comparison to type 1 diabetic subjects, patients with type 2 diabetes exhibited higher fatigue scores, notably in the dimensions of general fatigue, physical fatigue and reduced activity, together with greater levels of inflammatory markers that correlated with indexes of adiposity. Regression analyses controlling for diabetes duration, insulin treatment status, glycemic control and fasting status, indicated that levels of inflammatory markers, in particular hsIL-6, hsCRP and neopterin, were associated with MFI fatigue dimensions in type 2 diabetic patients. Mediation analyses revealed that adiposity did not significantly account for the relationship of inflammatory markers with fatigue scores albeit coefficient regressions decreased somewhat when this variable was controlled for in regression models. These findings indicate that systemic low-grade inflammation relates to fatigue symptoms in patients with type 2 diabetes and suggest the involvement of inflammatory processes in the pathophysiology of diabetes-related fatigue.
dc.language.isoENen_US
dc.subject.enAdiposity
dc.subject.enAdult
dc.subject.enAged
dc.subject.enBiomarkers
dc.subject.enDiabetes Mellitus
dc.subject.enType 2
dc.subject.enFatigue
dc.subject.enFemale
dc.subject.enHumans
dc.subject.enInflammation
dc.subject.enInterleukin-6
dc.subject.enMale
dc.subject.enMiddle Aged
dc.subject.enTumor Necrosis Factor-alpha
dc.title.enFatigue symptoms relate to systemic inflammation in patients with type 2 diabetes.
dc.title.alternativeBrain Behav Immunen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.bbi.2012.03.003en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed22469909en_US
bordeaux.journalBrain, Behavior, and Immunityen_US
bordeaux.page1211-9en_US
bordeaux.volume26en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue8en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDInstitut National de la Recherche Agronomiqueen_US
bordeaux.identifier.funderIDConseil Régional Aquitaineen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Brain,%20Behavior,%20and%20Immunity&rft.date=2012-11-01&rft.volume=26&rft.issue=8&rft.spage=1211-9&rft.epage=1211-9&rft.eissn=1090-2139&rft.issn=1090-2139&rft.au=LASSELIN,%20Julie&LAYE,%20Sophie&DEXPERT,%20Sandra&AUBERT,%20Agnes&GONZALEZ,%20Concepcion&rft.genre=article


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