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Serotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms.

dc.rights.licenseopenen_US
hal.structure.identifierUniversity of Barcelona
dc.contributor.authorUDINA, Marc
hal.structure.identifierUniversity of Barcelona
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorMORENO-ESPANA, Jose
hal.structure.identifierUniversity of Barcelona
hal.structure.identifierHospital del Mar Medical Research Institute [Barcelona, Spain] [IMIM]
dc.contributor.authorNAVINES, Ricard
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorGIMENEZ, Dolors
hal.structure.identifierHospital del Mar Medical Research Institute [Barcelona, Spain] [IMIM]
dc.contributor.authorLANGOHR, Klaus
hal.structure.identifierCentro de Regulación Genómica [CRG]
dc.contributor.authorGRATACOS, Monica
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorCAPURON, Lucile
IDREF: 167018736
hal.structure.identifierHospital del Mar Medical Research Institute [Barcelona, Spain] [IMIM]
dc.contributor.authorDE LA TORRE, Rafael
hal.structure.identifierUniversitat Autònoma de Barcelona = Autonomous University of Barcelona = Universidad Autónoma de Barcelona [UAB]
dc.contributor.authorSOLA, Ricard
hal.structure.identifierUniversity of Barcelona
hal.structure.identifierHospital del Mar Medical Research Institute [Barcelona, Spain] [IMIM]
dc.contributor.authorMARTIN-SANTOS, Rocio
dc.date.accessioned2022-03-23T11:20:18Z
dc.date.available2022-03-23T11:20:18Z
dc.date.issued2013-09-01
dc.identifier.issn1873-3360en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/136519
dc.description.abstractEnCytokines and serotonin neurotransmission may play an important role on the development of psychopathological symptoms during interferon (IFN) treatment. The aim of the present study was to investigate the association between IFN-induced depression, anxiety and fatigue and functional genetic variants at the interleukin-6 gene (IL-6) and serotonin transporter gene (SERT). 385 consecutive Caucasian outpatients with chronic hepatitis C initiating treatment with IFN-alpha and ribavirin were included. All patients were interviewed at baseline using the Structured Clinical Interview for DSM-IV (SCID-I) and those with a current major depressive disorder or anxiety disorder before starting treatment were excluded. Depression and anxiety were assessed at baseline during the treatment (at 4, 12, 24 and 48 weeks) using the Hospital Anxiety and Depression Scale and fatigue was evaluated using a visual analogue scale. The 5-HTTLPR region of SERT gene and the functional polymorphism located at the promoter region of IL-6 gene (rs1800795) were genotyped. Genotypic distribution was in the Hardy-Weinberg equilibrium for SERT (p=0.41) and for IL-6 (p=0.72) polymorphisms. At baseline we found only a significant effect of IL-6 polymorphism on fatigue symptoms. During antiviral treatment we reported that subjects with CC genotype (IL-6) presented significantly lower changes from baseline in IFN-induced depression (p=0.005) and IFN-induced anxiety (p=0.004). We did not find statistically significant differences on depression (p=0.21) or anxiety (p=0.15) between SS/SL and LL genotypes of SERT. Genetic variations in the IL-6 gene increase the risk of IFN-induced depression and anxiety. The IL-6 polymorphism was associated with fatigue rates in patients with chronic hepatitis C before treatment. Our study confirms the role of inflammatory mechanisms in IFN-induced psychopathological symptoms.
dc.language.isoENen_US
dc.subject.enAdult
dc.subject.enAnti-Anxiety Agents
dc.subject.enAntidepressive Agents
dc.subject.enAntiviral Agents
dc.subject.enAnxiety
dc.subject.enCohort Studies
dc.subject.enDepression
dc.subject.enDrug Therapy
dc.subject.enCombination
dc.subject.enFatigue
dc.subject.enGenetic Predisposition to Disease
dc.subject.enHepatitis C
dc.subject.enChronic
dc.subject.enHumans
dc.subject.enINDEL Mutation
dc.subject.enInterferon-alpha
dc.subject.enInterleukin-6
dc.subject.enMiddle Aged
dc.subject.enPoint Mutation
dc.subject.enPolyethylene Glycols
dc.subject.enPromoter Regions
dc.subject.enGenetic
dc.subject.enProspective Studies
dc.subject.enRecombinant Proteins
dc.subject.enRibavirin
dc.subject.enSerotonin
dc.subject.enSerotonin Plasma Membrane Transport Proteins
dc.subject.enWhites
dc.title.enSerotonin and interleukin-6: the role of genetic polymorphisms in IFN-induced neuropsychiatric symptoms.
dc.title.alternativePsychoneuroendocrinologyen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.psyneuen.2013.03.007en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed23571152en_US
bordeaux.journalPsychoneuroendocrinologyen_US
bordeaux.page1803-13en_US
bordeaux.volume38en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.import.sourcepubmed
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Psychoneuroendocrinology&rft.date=2013-09-01&rft.volume=38&rft.issue=9&rft.spage=1803-13&rft.epage=1803-13&rft.eissn=1873-3360&rft.issn=1873-3360&rft.au=UDINA,%20Marc&MORENO-ESPANA,%20Jose&NAVINES,%20Ricard&GIMENEZ,%20Dolors&LANGOHR,%20Klaus&rft.genre=article


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