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The translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.

dc.contributor.authorDEIWICK, Jörg
hal.structure.identifierCentre d'Immunologie de Marseille - Luminy [CIML]
dc.contributor.authorSALCEDO, Suzana P
hal.structure.identifierCentre d'Immunologie de Marseille - Luminy [CIML]
dc.contributor.authorBOUCROT, Emmanuel
dc.contributor.authorGILLILAND, Sarah M
hal.structure.identifierCentre d'Immunologie de Marseille - Luminy [CIML]
dc.contributor.authorHENRY, Thomas
dc.contributor.authorPETERMANN, Nele
dc.contributor.authorWATERMAN, Scott R
hal.structure.identifierCentre d'Immunologie de Marseille - Luminy [CIML]
dc.contributor.authorGORVEL, Jean-Pierre
dc.contributor.authorHOLDEN, David W
hal.structure.identifierCentre d'Immunologie de Marseille - Luminy [CIML]
dc.contributor.authorMÉRESSE, Stéphane
dc.date.issued2006-12
dc.identifier.issn0019-9567
dc.description.abstractEnThe facultative intracellular pathogen Salmonella enterica causes a variety of diseases, including gastroenteritis and typhoid fever. Inside epithelial cells, Salmonella replicates in vacuoles, which localize in the perinuclear area in close proximity to the Golgi apparatus. Among the effector proteins translocated by the Salmonella pathogenicity island 2-encoded type III secretion system, SifA and SseG have been shown necessary but not sufficient to ensure the intracellular positioning of Salmonella vacuoles. Hence, we have investigated the involvement of other secreted effector proteins in this process. Here we show that SseF interacts functionally and physically with SseG but not SifA and is also required for the perinuclear localization of Salmonella vacuoles. The observations show that the intracellular positioning of Salmonella vacuoles is a complex phenomenon resulting from the combined action of several effector proteins.
dc.language.isoen
dc.publisherAmerican Society for Microbiology
dc.subject.meshAnimals
dc.subject.meshBacterial Proteins
dc.subject.meshSalmonella enterica
dc.subject.meshVacuoles
dc.subject.meshCells, Cultured
dc.subject.meshGolgi Apparatus
dc.subject.meshHumans
dc.subject.meshMice
dc.subject.meshMice, Inbred Strains
dc.subject.meshProtein Interaction Mapping
dc.subject.meshProtein Structure, Tertiary
dc.subject.meshProtein Transport
dc.title.enThe translocated Salmonella effector proteins SseF and SseG interact and are required to establish an intracellular replication niche.
dc.typeArticle de revue
dc.identifier.doi10.1128/IAI.00648-06
dc.subject.halSciences du Vivant [q-bio]/Immunologie
bordeaux.journalInfection and Immunity
bordeaux.page6965-72
bordeaux.volume74
bordeaux.issue12
bordeaux.peerReviewedoui
hal.identifierhal-00165607
hal.version1
hal.origin.linkhttps://hal.archives-ouvertes.fr//hal-00165607v1
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