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Racial Residential Segregation in Young Adulthood and Brain Integrity in Middle Age: Can We Learn From Small Samples?

dc.rights.licenseopenen_US
dc.contributor.authorAL HAZZOURI, Adina Zeki
dc.contributor.authorJAWADEKAR, Neal
dc.contributor.authorKEZIOS, Katrina
dc.contributor.authorCAUNCA, Michelle R.
dc.contributor.authorELFASSY, Tali
dc.contributor.authorCALONICO, Sebastian
dc.contributor.authorKERSHAW, Kiarri N.
dc.contributor.authorYAFFE, Kristine
dc.contributor.authorLAUNER, Lenore
dc.contributor.authorELBEJJANI, Martine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorGRASSET, Leslie
dc.contributor.authorMANLY, Jennifer
dc.contributor.authorODDEN, Michelle C.
dc.contributor.authorGLYMOUR, M. Maria
dc.date.accessioned2022-03-04T09:16:23Z
dc.date.available2022-03-04T09:16:23Z
dc.date.issued2022-01-11
dc.identifier.issn1476-6256 (Electronic) 0002-9262 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/128823
dc.description.abstractEnRacial residential segregation is associated with multiple adverse health outcomes in Black individuals. Yet, the influence of structural racism and racial residential segregation on brain aging is less understood. In this study, we investigate the association between cumulative exposure to racial residential segregation over 25 years (1985-2010) of young adulthood, measured by the Getis-Ord Gi*-statistic, and year 25 measures of brain volume in midlife (cerebral, gray matter, white matter, and hippocampal volumes). We studied 290 Black participants with available brain imaging data who were enrolled in the Coronary Artery Risk Development in Young Adults (CARDIA) prospective cohort study. CARDIA originally recruited 2637 Black participants aged 18 to 30 years old from 4 field centers across the United States. We conducted analyses using marginal structural models, incorporating inverse probability weighting and inverse censoring weighting. We found that compared to low/medium segregation, greater cumulative exposure to residential segregation throughout young adulthood was associated with smaller brain volumes in general (e.g. β for cerebral volume: -0.08 [95% CI]: [-0.15, -0.02]) and with a more pronounced reduction in hippocampal volume, though results were not statistically significant. Our findings suggest that exposure to segregated neighborhoods may be associated with worse brain aging.
dc.language.isoENen_US
dc.subject.enBrain aging
dc.subject.enEpidemiologic methods
dc.subject.enMarginal structural models
dc.subject.enRacism
dc.subject.enSegregation
dc.title.enRacial Residential Segregation in Young Adulthood and Brain Integrity in Middle Age: Can We Learn From Small Samples?
dc.typeArticle de revueen_US
dc.identifier.doi10.1093/aje/kwab297en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed35020781en_US
bordeaux.journalAmerican Journal of Epidemiologyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamVINTAGEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03597125
hal.version1
hal.date.transferred2022-03-04T09:16:25Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=American%20Journal%20of%20Epidemiology&rft.date=2022-01-11&rft.eissn=1476-6256%20(Electronic)%200002-9262%20(Linking)&rft.issn=1476-6256%20(Electronic)%200002-9262%20(Linking)&rft.au=AL%20HAZZOURI,%20Adina%20Zeki&JAWADEKAR,%20Neal&KEZIOS,%20Katrina&CAUNCA,%20Michelle%20R.&ELFASSY,%20Tali&rft.genre=article


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