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Comparison of Simoa™ and Ella™ to assess serum neurofilament-light chain in multiple sclerosis

dc.rights.licenseopenen_US
dc.contributor.authorGAUTHIER, Audrey
dc.contributor.authorVIEL, Sebastien
dc.contributor.authorPERRET, Magali
dc.contributor.authorBROCARD, Guillaume
dc.contributor.authorCASEY, Romain
dc.contributor.authorLOMBARD, Christine
dc.contributor.authorLAURENT-CHABALIER, Sabine
dc.contributor.authorDEBOUVERIE, Marc
dc.contributor.authorEDAN, Gilles
dc.contributor.authorVUKUSIC, Sandra
dc.contributor.authorLEBRUN-FRENAY, Christine
dc.contributor.authorDE SEZE, Jerome
dc.contributor.authorLAPLAUD, David-Axel
dc.contributor.authorCASTELNOVO, Giovanni
dc.contributor.authorGOUT, Olivier
hal.structure.identifierService de neurologie [Bordeaux]
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorRUET, Aurelie
dc.contributor.authorMOREAU, Thibault
dc.contributor.authorCASEZ, Olivier
dc.contributor.authorCLAVELOU, Pierre
dc.contributor.authorBERGER, Eric
dc.contributor.authorZEPHIR, Helene
dc.contributor.authorTROUILLET-ASSANT, Sophie
dc.contributor.authorTHOUVENOT, Eric
dc.date.accessioned2022-02-18T15:31:06Z
dc.date.available2022-02-18T15:31:06Z
dc.date.issued2021-05
dc.identifier.issn2328-9503en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/128748
dc.description.abstractEnWe compared SimoaTM and EllaTM immunoassays to assess serum neurofilament-light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms. The EllaTM instrument overestimated values by 17%, but as the data were linear (p = 0.57), it was possible to apply a correction factor to EllaTM results. As for SimoaTM, serum neurofilament-light chain levels measured by EllaTM were correlated with age and EDSS and were significantly higher in active multiple sclerosis, suggesting that these assays are equivalent and can be used in routine clinical practice.
dc.description.sponsorshipObservatoire Français de la Sclérose en Plaquesen_US
dc.language.isoENen_US
dc.rightsAttribution-NonCommercial-NoDerivs 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/2.0/us/*
dc.title.enComparison of Simoa™ and Ella™ to assess serum neurofilament-light chain in multiple sclerosis
dc.title.alternativeAnn Clin Transl Neurolen_US
dc.typeArticle de revueen_US
dc.identifier.doi10.1002/acn3.51355en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed33830650en_US
bordeaux.journalAnnals of Clinical and Translational Neurologyen_US
bordeaux.page1141-1150en_US
bordeaux.volume8en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue5en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&amp;rft_val_fmt=info:ofi/fmt:kev:mtx:journal&amp;rft.jtitle=Annals%20of%20Clinical%20and%20Translational%20Neurology&amp;rft.date=2021-05&amp;rft.volume=8&amp;rft.issue=5&amp;rft.spage=1141-1150&amp;rft.epage=1141-1150&amp;rft.eissn=2328-9503&amp;rft.issn=2328-9503&amp;rft.au=GAUTHIER,%20Audrey&amp;VIEL,%20Sebastien&amp;PERRET,%20Magali&amp;BROCARD,%20Guillaume&amp;CASEY,%20Romain&amp;rft.genre=article


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