Agricultural exposure and risk of soft tissue sarcomas and gastrointestinal stromal sarcoma in the AGRIculture and CANcer (AGRICAN) cohort
| dc.rights.license | open | en_US |
| dc.contributor.author | RENIER, Marine | |
| dc.contributor.author | BUSSON, Amandine | |
| dc.contributor.author | BOULANGER, Mathilde | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | PIEL, Clement | |
| dc.contributor.author | PONS, Romain | |
| dc.contributor.author | TUAL, Severine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | AMADEO, Brice | |
| dc.contributor.author | MERYET-FIGUIERE, Matthieu | |
| dc.contributor.author | MARCOTULLIO, Elisabeth | |
| dc.contributor.author | CLIN, Benedicte | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | BALDI, Isabelle | |
| dc.contributor.author | LEBAILLY, Pierre | |
| dc.date.accessioned | 2022-02-16T15:51:39Z | |
| dc.date.available | 2022-02-16T15:51:39Z | |
| dc.date.issued | 2022-01-19 | |
| dc.identifier.issn | 1097-0215 (Electronic) 0020-7136 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124749 | |
| dc.description.abstractEn | BACKGROUND: Sarcomas are a heterogeneous group of tumors whose incidence is nearly 5 per 100 000 inhabitants in Europe. Their causes are poorly understood, although occupational exposures (especially farming and pesticides) are suspected. METHODS: The AGRICAN cohort is a prospective study of 181,842 individuals enrolled in 2005-2007 who completed an enrolment questionnaire with data on lifelong agricultural exposure. Associations between agricultural exposure and sarcoma overall, GIST (gastro-intestinal stromal tumors) and myomatous and fibrous sarcoma together, were analyzed with a Cox model. RESULTS: Until 2015, 188 incident cases of sarcoma were identified. Increased risks were observed (1) among cattle farmers working < 10 years (HR(<10years) =2.45, 95%CI 1.36-4.43) and breeding ≥ 50 livestock (HR(≥50 animals) =3.84, 95%CI 1.60-9.22), especially if involved in animal care and building disinfection, (2) in greenhouse production (HR=1.82, 95%CI 1.01-3.30), and (3) in field-grown vegetable production (HR=1.49, 95%CI 0.96-2.32). Concerning histological subtypes, GIST were positively associated with pesticide use in vineyards (HR=2.24, 95%CI 0.95-5.30). For myomatous and fibrous sarcoma, the only increase was seen in field-grown vegetable production (HR=2.37, 95%CI 1.16-4.85). CONCLUSION: In AGRICAN, the risk of sarcomas was increased in several farming activities with differences according to histological subtype. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Cohort | |
| dc.subject.en | Farming | |
| dc.subject.en | Occupational exposure | |
| dc.subject.en | Pesticides | |
| dc.subject.en | Sarcoma | |
| dc.title.en | Agricultural exposure and risk of soft tissue sarcomas and gastrointestinal stromal sarcoma in the AGRIculture and CANcer (AGRICAN) cohort | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1002/ijc.33936 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 35048371 | en_US |
| bordeaux.journal | International Journal of Cancer | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | EPICENE_BPH | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| bordeaux.identifier.funderID | Agence Nationale de Sécurité Sanitaire de l’Alimentation, de l’Environnement et du Travail | en_US |
| bordeaux.identifier.funderID | Association pour la Recherche sur le Cancer | en_US |
| bordeaux.identifier.funderID | Institut National Du Cancer | en_US |
| bordeaux.identifier.funderID | Ligue Contre le Cancer | en_US |
| bordeaux.identifier.funderID | Ministère de l'Enseignement Supérieur et de la Recherche Scientifique | en_US |
| bordeaux.identifier.funderID | Mutualité Sociale Agricole | en_US |
| bordeaux.identifier.funderID | Office National de l’Eau et des Milieux Aquatiques | en_US |
| bordeaux.identifier.funderID | Fondation de France | en_US |
| hal.identifier | hal-03577444 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-02-16T15:51:42Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Cancer&rft.date=2022-01-19&rft.eissn=1097-0215%20(Electronic)%200020-7136%20(Linking)&rft.issn=1097-0215%20(Electronic)%200020-7136%20(Linking)&rft.au=RENIER,%20Marine&BUSSON,%20Amandine&BOULANGER,%20Mathilde&PIEL,%20Clement&PONS,%20Romain&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||