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Subcellular specificity of cannabinoid effects in striatonigral circuits

dc.rights.licenseopenen_US
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorSORIA-GOMEZ, Edgar
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorPAGANO ZOTTOLA, Antonio C.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARIANI, Yamuna
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorDESPREZ, Tifany
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBARRESI, Massimo
dc.contributor.authorBONILLA-DEL-RIO, Itziar
dc.contributor.authorMUGURUZA, Carolina
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorLE BON-JEGO, Morgane
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorJULIO-KALAJZIC, Francisca
dc.contributor.authorFLYNN, Robyn
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorTERRAL, Geoffrey
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorFERNANDEZ-MONCADA, Ignacio
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorROBIN, Laurie M.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorOLIVEIRA DA CRUZ, Jose F.
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCORINTI, Simone
dc.contributor.authorOULD AMER, Yasmine
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorGONCALVES, Julia
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVARILH, Marjorie
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCANNICH, Astrid
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorREDON, Bastien
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorZHAO, Zhe
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorLESTE-LASSERRE, Thierry
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorVINCENT, Peggy
dc.contributor.authorTOLENTINO-CORTEZ, Tarson
dc.contributor.authorPUENTE, Nagore
dc.contributor.authorBAINS, Jaideep S
dc.contributor.authorHEBERT-CHATELAIN, Etienne
dc.contributor.authorBARREDA-GOMEZ, Gabriel
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorCHAOULOFF, Francis
dc.contributor.authorLOHMAN, Alexander W.
dc.contributor.authorCALLADO, Luis F.
dc.contributor.authorGRANDES, Pedro
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorBAUFRETON, Jerome
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorMARSICANO, Giovanni
hal.structure.identifierNeurocentre Magendie : Physiopathologie de la Plasticité Neuronale [U1215 Inserm - UB]
dc.contributor.authorBELLOCCHIO, Luigi
dc.date.accessioned2022-02-07T15:27:28Z
dc.date.available2022-02-07T15:27:28Z
dc.date.issued2021-05-05
dc.identifier.issn0896-6273en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124679
dc.description.abstractEnRecent advances in neuroscience have positioned brain circuits as key units in controlling behavior, implying that their positive or negative modulation necessarily leads to specific behavioral outcomes. However, emerging evidence suggests that the activation or inhibition of specific brain circuits can actually produce multimodal behavioral outcomes. This study shows that activation of a receptor at different subcellular locations in the same neuronal circuit can determine distinct behaviors. Pharmacological activation of type 1 cannabinoid (CB1) receptors in the striatonigral circuit elicits both antinociception and catalepsy in mice. The decrease in nociception depends on the activation of plasma membrane-residing CB1 receptors (pmCB1), leading to the inhibition of cytosolic PKA activity and substance P release. By contrast, mitochondrial-associated CB1 receptors (mtCB1) located at the same terminals mediate cannabinoid-induced catalepsy through the decrease in intra-mitochondrial PKA-dependent cellular respiration and synaptic transmission. Thus, subcellular-specific CB1 receptor signaling within striatonigral circuits determines multimodal control of behavior.
dc.language.isoENen_US
dc.rights*
dc.rights.uri*
dc.subject.enAntinociception
dc.subject.enCatalepsy
dc.subject.enCB1 receptor
dc.subject.enMitochondria
dc.subject.enPKA
dc.subject.enSubstance P
dc.subject.enSubstantia nigra
dc.subject.enTHC
dc.title.enSubcellular specificity of cannabinoid effects in striatonigral circuits
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.neuron.2021.03.007en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
bordeaux.journalNeuronen_US
bordeaux.page1513-1526.e11en_US
bordeaux.volume109en_US
bordeaux.hal.laboratoriesNeurocentre Magendie - UMR-S 1215en_US
bordeaux.issue9en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Neuron&rft.date=2021-05-05&rft.volume=109&rft.issue=9&rft.spage=1513-1526.e11&rft.epage=1513-1526.e11&rft.eissn=0896-6273&rft.issn=0896-6273&rft.au=SORIA-GOMEZ,%20Edgar&PAGANO%20ZOTTOLA,%20Antonio%20C.&MARIANI,%20Yamuna&DESPREZ,%20Tifany&BARRESI,%20Massimo&rft.genre=article


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