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Incidence of lung and HPV-associated malignancies in HIV-infected patients

dc.rights.licenseopenen_US
dc.contributor.authorCHAUSSADE, Helene
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE-MAREC, Fabien
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCOUREAU, Gaelle
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLELEUX, Olivier
dc.contributor.authorNEAU, Didier
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorLAZARO, Estibaliz
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorAMADEO, Brice
hal.structure.identifierImmunology from Concept and Experiments to Translation [ImmunoConcept]
dc.contributor.authorDUFFAU, Pierre
dc.contributor.authorFERRAND, Helene
dc.contributor.authorCOURTAULT, Carine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorFOUCAN, Anne Sophie
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorWITTKOP, Linda
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorBONNET, Fabrice
dc.date.accessioned2022-01-20T10:22:35Z
dc.date.available2022-01-20T10:22:35Z
dc.date.issued2021-12-17
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124448
dc.description.abstractEnOBJECTIVE: Cancers represent one of the leading cause of mortality/morbidity in patients living with HIV (PLHIV) in industrialized countries. The objective of our study was to compare incidence of lung and HPV-related cancers among PLHIV with general population over the 2010-2017 period.Design: Prospective and multicenter cohort study. METHODS: The study included patients with lung and HPV-related cancers from the ANRS CO3 Aquitaine cohort (PLHIV) and the general population-based cancer registry in Gironde area. We calculated incidence rates (IR) for 100,000 Person Year (PY) and Incidence Rate Ratios (IRR). RESULTS: Among the 3,572 PLHIV, 70 cancers were diagnosed in 68 patients including 35 lung and 35 HPV-related cancers (18 oropharyngeal, 11 anal, 6 cervix). IR of lung and HPV-related-cancers were 311.1 in PLHIV and 209.8 in general population for 100,000 PY, respectively. IRR were significantly increased in PLHIV for lung 1.8 [1.4; 2.2] and HPV-related cancer 1.3 [1.0; 1.6] and particularly high for patients between 40-49 years-old (IRR 4.4 [2.3; 8.4] for lung cancer and 3.7 [2.1; 6.5] for HPV-related cancer). CONCLUSIONS: We emphasized the persistent high risk of lung and HPV-related cancer despite advent of antiretroviral therapies, particularly in the age strata of 40-49 years. Screening procedures should take into account this finding.
dc.language.isoENen_US
dc.subject.enAnus neoplasms
dc.subject.enCancer HPV
dc.subject.enHIV-1
dc.subject.enLung cancer
dc.subject.enOropharyngeal neoplasms
dc.subject.enUterine cervical neoplasms
dc.title.enIncidence of lung and HPV-associated malignancies in HIV-infected patients
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/QAD.0000000000003152en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34923517en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.institutionCNRS
bordeaux.teamEPICENEen_US
bordeaux.teamEPICENE_BPH
bordeaux.teamMORPH3Eusen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.exportfalse
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=AIDS.%20Official%20journal%20of%20the%20international%20AIDS%20Society&rft.date=2021-12-17&rft.eissn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.issn=1473-5571%20(Electronic)%200269-9370%20(Linking)&rft.au=CHAUSSADE,%20Helene&LE-MAREC,%20Fabien&COUREAU,%20Gaelle&LELEUX,%20Olivier&NEAU,%20Didier&rft.genre=article


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