Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis
| dc.rights.license | open | en_US |
| dc.contributor.author | ANTONAZZO, Ippazio Cosimo | |
| dc.contributor.author | FORNARI, Carla | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | MAUMUS-ROBERT, Sandy | |
| dc.contributor.author | CEI, Eleonora | |
| dc.contributor.author | PAOLETTI, Olga | |
| dc.contributor.author | CONTI, Sara | |
| dc.contributor.author | CORTESI, Paolo Angelo | |
| dc.contributor.author | MANTOVANI, Lorenzo Giovanni | |
| dc.contributor.author | GINI, Rosa | |
| dc.contributor.author | MAZZAGLIA, Giampiero | |
| dc.date.accessioned | 2022-01-20T08:48:59Z | |
| dc.date.available | 2022-01-20T08:48:59Z | |
| dc.date.issued | 2021-12-16 | |
| dc.identifier.issn | 1660-4601 | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124446 | |
| dc.description.abstractEn | BACKGROUND: In 2020, during the COVID-19 pandemic, Italy implemented two national lockdowns aimed at reducing virus transmission. We assessed whether these lockdowns affected anti-seizure medication (ASM) use and epilepsy-related access to emergency departments (ED) in the general population. METHODS: We performed a population-based study using the healthcare administrative database of Tuscany. We defined the weekly time series of prevalence and incidence of ASM, along with the incidence of epilepsy-related ED access from 1 January 2018 to 27 December 2020 in the general population. An interrupted time-series analysis was used to assess the effect of lockdowns on the observed outcomes. RESULTS: Compared to pre-lockdown, we observed a relevant reduction of ASM incidence (0.65; 95% Confidence Intervals: 0.59-0.72) and ED access (0.72; 0.64-0.82), and a slight decrease of ASM prevalence (0.95; 0.94-0.96). During the post-lockdown the ASM incidence reported higher values compared to pre-lockdown, whereas ASM prevalence and ED access remained lower. Results also indicate a lower impact of the second lockdown for both ASM prevalence (0.97; 0.96-0.98) and incidence (0.89; 0.80-0.99). CONCLUSION: The lockdowns implemented during the COVID-19 outbreaks significantly affected ASM use and epilepsy-related ED access. The potential consequences of these phenomenon are still unknown, although an increased incidence of epilepsy-related symptoms after the first lockdown has been observed. These findings emphasize the need of ensuring continuous care of epileptic patients in stressful conditions such as the COVID-19 pandemic. | |
| dc.language.iso | EN | en_US |
| dc.rights | Attribution 3.0 United States | * |
| dc.rights.uri | http://creativecommons.org/licenses/by/3.0/us/ | * |
| dc.subject.en | COVID-19 | |
| dc.subject.en | Italy | |
| dc.subject.en | Epilepsy | |
| dc.subject.en | Anti-seizure medication | |
| dc.subject.en | Emergency department access | |
| dc.subject.en | Time-series analysis | |
| dc.title.en | Impact of COVID-19 Lockdown, during the Two Waves, on Drug Use and Emergency Department Access in People with Epilepsy: An Interrupted Time-Series Analysis | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3390/ijerph182413253 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34948862 | en_US |
| bordeaux.journal | International Journal of Environmental Research and Public Health | en_US |
| bordeaux.volume | 18 | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.issue | 24 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | PharmacoEpi-Drugs | en_US |
| bordeaux.team | AHeaD | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03536686 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-01-20T08:49:03Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=International%20Journal%20of%20Environmental%20Research%20and%20Public%20Health&rft.date=2021-12-16&rft.volume=18&rft.issue=24&rft.eissn=1660-4601&rft.issn=1660-4601&rft.au=ANTONAZZO,%20Ippazio%20Cosimo&FORNARI,%20Carla&MAUMUS-ROBERT,%20Sandy&CEI,%20Eleonora&PAOLETTI,%20Olga&rft.genre=article |
