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Association Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes

dc.rights.licenseopenen_US
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorMOHAMMEDI, Kamel
dc.contributor.authorABOULEKA, Yawa
dc.contributor.authorCARPENTIER, Charlyne
dc.contributor.authorPOTIER, Louis
dc.contributor.authorDUBOIS, Severine
hal.structure.identifierBiologie des maladies cardiovasculaires = Biology of Cardiovascular Diseases
dc.contributor.authorFOUSSARD, Ninon
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorRIGALLEAU, Vincent
dc.contributor.authorGAUTIER, Jean Francois
dc.contributor.authorGOURDY, Pierre
dc.contributor.authorCHARPENTIER, Guillaume
dc.contributor.authorROUSSEL, Ronan
dc.contributor.authorSCHEEN, Andre
dc.contributor.authorBAUDUCEAU, Bernard
dc.contributor.authorHADJADJ, Samy
dc.contributor.authorALHENC-GELAS, Francois
dc.contributor.authorMARRE, Michel
dc.contributor.authorVELHO, Gilberto
dc.date.accessioned2022-01-18T15:29:10Z
dc.date.available2022-01-18T15:29:10Z
dc.date.issued2021-12-01
dc.identifier.issn1935-5548 (Electronic) 0149-5992 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124427
dc.description.abstractEnOBJECTIVE: The ACE insertion/deletion (I/D) polymorphism has been widely studied in people with diabetes, albeit not with regard to lower-limb amputation (LLA). We examined associations among this polymorphism, plasma ACE concentration, and LLA in people with type 1 diabetes. RESEARCH DESIGN AND METHODS: ACE I/D genotype and plasma ACE were assessed in three prospective cohorts of participants with type 1 diabetes. LLA was defined as minor (below-the-ankle amputation consisting of at least one ray metatarsal resection) or major (transtibial or transfemoral) amputation. Linear, logistic, and Cox regression models were computed to evaluate the likelihood of prevalent and incident LLA by ACE genotype (XD [ID or ID] vs. II) and plasma ACE, after adjusting for confounders. RESULTS: Among 1,301 participants (male 54%, age 41 ± 13 years), 90 (6.9%) had a baseline history of LLA. Baseline LLA was more prevalent in XD (7.4%) than in II genotype (4.5%, odds ratio [OR] 2.17 [95%CI 1.03-4.60]). Incident LLA occurred in 53 individuals during the 14-year follow-up and was higher in XD versus II carriers (hazard ratio 3.26 [95% CI 1.16-13.67]). This association was driven by excess risk of minor, but not major, LLA. The D allele was associated with increased prevalent LLA at the end of follow-up (OR 2.48 [1.33-4.65]). LLA was associated with higher mean (95% CI) ACE levels in II (449 [360, 539] vs. 354 [286, 423] ng/mL), but not XD (512 [454, 570] vs. 537 [488, 586]), carriers. CONCLUSIONS: This report is the first of an independent association between ACE D allele and excess LLA risk, mainly minor amputations, in patients with type 1 diabetes.
dc.language.isoENen_US
dc.title.enAssociation Between the ACE Insertion/Deletion Polymorphism and Risk of Lower-Limb Amputation in Patients With Long-Standing Type 1 Diabetes
dc.typeArticle de revueen_US
dc.identifier.doi10.2337/dc21-0973en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34853028en_US
bordeaux.journalDiabetes careen_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamLEHA_BPH
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03533116
hal.version1
hal.date.transferred2022-01-18T15:29:13Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Diabetes%20care&rft.date=2021-12-01&rft.eissn=1935-5548%20(Electronic)%200149-5992%20(Linking)&rft.issn=1935-5548%20(Electronic)%200149-5992%20(Linking)&rft.au=MOHAMMEDI,%20Kamel&ABOULEKA,%20Yawa&CARPENTIER,%20Charlyne&POTIER,%20Louis&DUBOIS,%20Severine&rft.genre=article


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