Ambulatory blood pressure and drug treatment for orthostatic hypotension as predictors of mortality in patients with Multiple System Atrophy
| dc.rights.license | open | en_US |
| dc.contributor.author | PAVY-LE TRAON, Anne | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIER FOUBERT, Alexandra | |
| dc.contributor.author | ORY-MAGNE, Fabienne | |
| dc.contributor.author | FABBRI, Margherita | |
| dc.contributor.author | SENARD, Jean Michel | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | MEISSNER, Wassilios
IDREF: 113664761 | |
| dc.contributor.author | RASCOL, Olivier | |
| dc.contributor.author | AMAR, Jacques | |
| dc.date.accessioned | 2022-01-18T14:03:15Z | |
| dc.date.available | 2022-01-18T14:03:15Z | |
| dc.date.issued | 2021-12-31 | |
| dc.identifier.issn | 1468-1331 (Electronic) 1351-5101 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124422 | |
| dc.description.abstractEn | OBJECTIVES: Multiple system atrophy (MSA) is a rare fatal neurodegenerative disease characterized by parkinsonism, cerebellar ataxia and autonomic failure. This study aimed at investigating possible associations between mortality, 24H blood pressure (BP) level and variability, and drug treatments for orthostatic hypotension (OH) in MSA patients. METHODS: One hundred and twenty-nine patients followed at the French Reference Center for MSA who underwent routine 24H ambulatory BP monitoring, were included. Unified MSA Rating Scale (UMSARS) scores, drug treatments and the occurrence and cause of death were recorded. RESULTS: Seventy patients died during follow-up (2.9+/-1.8 years), mainly from terminal illness, pulmonary or sudden death. Multivariate Cox regression analysis, after adjustment for gender, disease duration and severity (UMSARS I+II score), showed that increased daytime systolic BP variability, OH severity and OH drug treatment were independently correlated with mortality. OH treatment was associated with the risk of cardiac causes and/or sudden death (p=0.01). In a fully adjusted model, male gender [(female vs male) Hazard ratio (HR): 0.56 95% CI [0.34-0.94] p=0.03], UMSARS I+II score [HR: 1.04 95% CI [1.02-1.06] p<0.01], systolic BP daytime variability [HR: 3.66 95% CI (1.46-9.17 p<0.01] and OH treatment [HR: 2.13 95 % CI [1.15- 3.94]; p=0.02] predicted mortality. CONCLUSION: Increased daytime BP variability and OH treatment were predictive of mortality in patients with MSA, independently from disease severity. Further studies are required to assess if these associations are explained by more severe autonomic dysfunction or if OH treatment exposes "per se" to a specific risk in this population. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Autonomic failure | |
| dc.subject.en | Blood pressure | |
| dc.subject.en | Multiple System Atrophy | |
| dc.subject.en | Orthostatic hypotension | |
| dc.subject.en | Treatment | |
| dc.title.en | Ambulatory blood pressure and drug treatment for orthostatic hypotension as predictors of mortality in patients with Multiple System Atrophy | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.1111/ene.15232 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34971021 | en_US |
| bordeaux.journal | European Journal of Neurology | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.team | ACTIVE (2022) | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03532455 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-01-18T14:03:17Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=European%20Journal%20of%20Neurology&rft.date=2021-12-31&rft.eissn=1468-1331%20(Electronic)%201351-5101%20(Linking)&rft.issn=1468-1331%20(Electronic)%201351-5101%20(Linking)&rft.au=PAVY-LE%20TRAON,%20Anne&SAMIER%20FOUBERT,%20Alexandra&ORY-MAGNE,%20Fabienne&FABBRI,%20Margherita&SENARD,%20Jean%20Michel&rft.genre=article |
Fichier(s) constituant ce document
| Fichiers | Taille | Format | Vue |
|---|---|---|---|
|
Il n'y a pas de fichiers associés à ce document. |
|||