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dc.rights.licenseopenen_US
dc.contributor.authorRONCHETTI, Anne Marie
dc.contributor.authorMATHERON, Sophie
dc.contributor.authorGALICIER, Lionel
dc.contributor.authorDAMOND, Florence
dc.contributor.authorMAHJOUB, Nadia
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorCHAGHIL-BOISSIERE, Nathalie
dc.contributor.authorMEIGNIN, Veronique
dc.contributor.authorMECHAI, Frederic
dc.contributor.authorSIMON, Francois
dc.contributor.authorOKSENHENDLER, Eric
dc.contributor.authorGERARD, Laurence
dc.date.accessioned2022-01-17T09:12:16Z
dc.date.available2022-01-17T09:12:16Z
dc.date.issued2021-11-15
dc.identifier.issn1473-5571 (Electronic) 0269-9370 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124402
dc.description.abstractEnOBJECTIVE: To describe lymphoma in HIV-2-infected patients and compare their characteristics with lymphoma in HIV-1-infected patients. DESIGN: Ancillary analysis from a single center prospective cohort of HIV-lymphoma. METHODS: We report on 16 patients with HIV-2-lymphoma diagnosed after 1996 and included in a prospective cohort of HIV lymphoma. Five additional HIV-2-infected patients coinfected with HIV-1 or/and HTLV-I (6 lymphomas) are separately reported. The incidence of lymphoma in HIV-2-infected patients was evaluated in the French multicentric HIV-2 cohort. RESULTS: Incidence of lymphoma in the French HIV-2 cohort was estimated as 0.6/1000 patient-years. In our series, the median CD4+ cell count was 166 × 106/l at the time of lymphoma diagnosis and 50% of patients had undetectable plasma HIV-2-RNA. Lymphomas were non-Hodgkin lymphoma (n = 12) and classical Hodgkin lymphoma (n = 4). Similarly to HIV-1-lymphoma, clinical presentation was aggressive in most cases. All but one patient received intensive chemotherapy. Complete remission was achieved in 13 cases and 1 patient relapsed. The overall survival was not statistically different from that observed in patients with HIV-1 lymphoma. The six additional lymphomas observed in five HIV-2-infected patients coinfected with HIV-1 or/and HTLV-I presented with similar clinical presentation but worse prognosis. CONCLUSION: Despite the lower pathogenicity of HIV-2, the risk of developing lymphoma seems to be close to that observed in HIV-1 population with similar lymphoma characteristics. Compared with HIV-1, HIV-2-infected patients developed lymphoma later in their life but at a similar CD4+ cell count level.
dc.language.isoENen_US
dc.subject.enAdult T cell leukemia-lymphoma
dc.subject.enChemotherapy
dc.subject.enHIV-2
dc.subject.enHodgkin lymphoma
dc.subject.enHTLV-I infections
dc.subject.enNon-Hodgkin lymphoma
dc.subject.enTreatment outcome
dc.title.enLymphoma in HIV-2-infected patients in combination antiretroviral therapy era
dc.typeArticle de revueen_US
dc.identifier.doi10.1097/QAD.0000000000003015en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34231524en_US
bordeaux.journalAIDS. Official journal of the international AIDS Societyen_US
bordeaux.page2299-2309en_US
bordeaux.volume35en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.issue14en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03528161
hal.version1
hal.date.transferred2022-01-17T09:12:18Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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