A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community
| dc.rights.license | open | en_US |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | NEUFFER, Jeanne
ORCID: 0000-0002-3667-6948 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | GOURRU, Marjorie | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | THOMAS, Aline | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | LEFEVRE ARBOGAST, Sophie | |
| hal.structure.identifier | Institut des Maladies Neurodégénératives [Bordeaux] [IMN] | |
| dc.contributor.author | SAMIER FOUBERT, Alexandra | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | HELMER, Catherine | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | DELCOURT, Cecile
ORCID: 0000-0002-2099-0481 IDREF: 035105291 | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | FEART-COURET, Catherine
ORCID: 0000-0002-7959-1610 IDREF: 08195848X | |
| hal.structure.identifier | Bordeaux population health [BPH] | |
| dc.contributor.author | SAMIERI, Cecilia | |
| dc.date.accessioned | 2022-01-14T14:51:36Z | |
| dc.date.available | 2022-01-14T14:51:36Z | |
| dc.date.issued | 2021-11-18 | |
| dc.identifier.issn | 1875-8908 (Electronic) 1387-2877 (Linking) | en_US |
| dc.identifier.uri | https://oskar-bordeaux.fr/handle/20.500.12278/124396 | |
| dc.description.abstractEn | BACKGROUND: Low blood status in several nutritional compounds, including long-chain omega-3 fatty acids (LC n-3 PUFA), carotenoids, and vitamin D, have been associated with a higher risk to develop dementia. Nutritional deficiencies may potentiate each other regarding dementia risk; yet the association of multiple nutritional deficiencies with dementia has been little explored. OBJECTIVE: To develop an index of micronutritional biological status (MNBS) for the screening of multi-micronutritional deficiencies associated with the risk of dementia in a prospective population-based cohort of older persons. METHODS: We included participants from the Bordeaux Three-City study, who were free of dementia at baseline, had blood measurements of LC n-3 PUFA, carotenoids, and 25(OH)D, and who were followed for up to 18 years for dementia. We used penalized splines in Cox models to model dose-response relationships of each nutritional component with the risk of dementia and construct a risk index. RESULTS: 629 participants with an average age of 73.1 years were included in the study. Each increase of 1 SD of the MNBS index was associated with a 46%higher risk of dementia (HR = 1.46, 95%CI 1.23; 1.73). Participants with highest index ([mean+1SD; max]) had a 4-fold increased risk of dementia compared with participants with a low index ([min; mean-1SD]) (HR = 4.17, 95%CI 2.30; 7.57). CONCLUSION: This index of assessment of micronutritional biological status is a practical tool that may help identify populations with inadequate nutritional status, screen eligible individuals for nutritional prevention in primary care, or for supplementation in preventive trials of dementia. | |
| dc.language.iso | EN | en_US |
| dc.subject.en | Biomarkers | |
| dc.subject.en | Cognitive aging | |
| dc.subject.en | Dementia | |
| dc.subject.en | Diet | |
| dc.subject.en | Elderly | |
| dc.subject.en | Food | |
| dc.subject.en | Molecular epidemiology | |
| dc.subject.en | Nutrients | |
| dc.subject.en | Nutritional status | |
| dc.subject.en | Prevention | |
| dc.title.en | A Biological Index to Screen Multi-Micronutrient Deficiencies Associated with the Risk to Develop Dementia in Older Persons from the Community | |
| dc.type | Article de revue | en_US |
| dc.identifier.doi | 10.3233/JAD-215011 | en_US |
| dc.subject.hal | Sciences du Vivant [q-bio]/Santé publique et épidémiologie | en_US |
| dc.identifier.pubmed | 34806604 | en_US |
| bordeaux.journal | Journal of Alzheimer's disease | en_US |
| bordeaux.hal.laboratories | Bordeaux Population Health Research Center (BPH) - UMR 1219 | en_US |
| bordeaux.institution | Université de Bordeaux | en_US |
| bordeaux.institution | INSERM | en_US |
| bordeaux.team | SEPIA | en_US |
| bordeaux.peerReviewed | oui | en_US |
| bordeaux.inpress | non | en_US |
| hal.identifier | hal-03526605 | |
| hal.version | 1 | |
| hal.date.transferred | 2022-01-14T14:51:39Z | |
| hal.export | true | |
| dc.rights.cc | Pas de Licence CC | en_US |
| bordeaux.COinS | ctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=Journal%20of%20Alzheimer's%20disease&rft.date=2021-11-18&rft.eissn=1875-8908%20(Electronic)%201387-2877%20(Linking)&rft.issn=1875-8908%20(Electronic)%201387-2877%20(Linking)&rft.au=NEUFFER,%20Jeanne&GOURRU,%20Marjorie&THOMAS,%20Aline&LEFEVRE%20ARBOGAST,%20Sophie&SAMIER%20FOUBERT,%20Alexandra&rft.genre=article |
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