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An Item Response Theory analysis of the Unified Multiple System Atrophy Rating Scale

dc.rights.licenseopenen_US
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAMIER FOUBERT, Alexandra
dc.contributor.authorPAVY-LE TRAON, Anne
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorSAULNIER, Tiphaine
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorLE GOFF, Melanie
ORCID: 0000-0003-2848-6287
dc.contributor.authorFABBRI, Margherita
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorHELMER, Catherine
dc.contributor.authorRASCOL, Olivier
hal.structure.identifierBordeaux population health [BPH]
dc.contributor.authorPROUST-LIMA, Cecile
hal.structure.identifierInstitut des Maladies Neurodégénératives [Bordeaux] [IMN]
dc.contributor.authorMEISSNER, Wassilios
IDREF: 113664761
dc.date.accessioned2022-01-14T09:07:40Z
dc.date.available2022-01-14T09:07:40Z
dc.date.issued2021-11-30
dc.identifier.issn1873-5126 (Electronic) 1353-8020 (Linking)en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124384
dc.description.abstractEnINTRODUCTION: The Unified Multiple System Atrophy Rating Scale (UMSARS) has four subscales that have been specifically designed for the clinical assessment of MSA patients. UMSARS I (activities of daily living) and II (motor examination) subscales are regularly used as primary endpoints in treatment trials. The main objective of this study was to identify UMSARS I and II subscale items that best describe progression over time. METHODS: All MSA patients seen at the French Reference Centre for MSA from 2007 to 2020 were included in a prospective cohort with an annual follow-up assessment including UMSARS. The repeated measures of the 26 UMSARS I and II items were analyzed using a longitudinal Item Response Theory model to identify the most informative items for each of the five UMSARS IV disease stages. Sample size estimates were further calculated for the most informative items as a group. RESULTS: A total of 557 MSA patients were included with a mean follow-up of 2.3 years. The majority of items progressed with disease duration or across the different UMSARS IV disability stages, with the exception of those related to dysautonomia. Roughly 70% of the scale information was carried by only 11/26 items, many reflecting the patient perspective. These yielded similar sample size estimates than UMSARS I + II items. CONCLUSION: This study provides important information about the progression of UMSARS I and II subscale items. Improvements seem particularly necessary regarding those assessing dysautonomia. A shortened scale may be useful as outcome for future clinical trials.
dc.language.isoENen_US
dc.subject.enMultiple system atrophy
dc.subject.enUnified Multiple System Atrophy Rating Scale
dc.subject.enEvaluation
dc.title.enAn Item Response Theory analysis of the Unified Multiple System Atrophy Rating Scale
dc.typeArticle de revueen_US
dc.identifier.doi10.1016/j.parkreldis.2021.11.024en_US
dc.subject.halSciences du Vivant [q-bio]/Santé publique et épidémiologieen_US
dc.identifier.pubmed34875563en_US
bordeaux.journalParkinsonism and Related Disordersen_US
bordeaux.page40-44en_US
bordeaux.volume94en_US
bordeaux.hal.laboratoriesBordeaux Population Health Research Center (BPH) - UMR 1219en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINSERMen_US
bordeaux.teamBIOSTAT_BPHen_US
bordeaux.teamSEPIAen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
hal.identifierhal-03525844
hal.version1
hal.date.transferred2022-01-14T09:08:33Z
hal.exporttrue
dc.rights.ccPas de Licence CCen_US
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