Mostrar el registro sencillo del ítem

dc.rights.licenseopenen_US
dc.contributor.authorDELPIERRE, Cyrille
dc.contributor.authorFANTIN, Romain
dc.contributor.authorBARBOZA-SOLIS, Christina
dc.contributor.authorLEPAGE, Benoit
hal.structure.identifierNutrition et Neurobiologie intégrée [NutriNeuro]
dc.contributor.authorDARNAUDERY, Muriel
IDREF: 124892264
dc.contributor.authorKELLY-IRVING, Michelle
dc.date.accessioned2022-01-13T15:22:33Z
dc.date.available2022-01-13T15:22:33Z
dc.date.issued2016-08-18
dc.identifier.issn1471-2458en_US
dc.identifier.urihttps://oskar-bordeaux.fr/handle/20.500.12278/124378
dc.description.abstractEnBackground: Lifecourse studies suggest that the metabolic syndrome (MetS) may be rooted in the early life environment. This study aims to examine the pathways linking early nutritional and psychosocial exposures and the presence of MetS in midlife. Methods: Data are from the National Child Development Study including individuals born during 1 week in 1958 in Great Britain and followed-up until now. MetS was defined based on the National Cholesterol Education Program Adult Treatment Panel III classification. Mother’s pre-pregnancy body mass index (BMI) was used as a proxy of the early nutritional environment and Adverse Childhood Experiences (ACE) as a proxy for early psychosocial stress. Socioeconomic characteristics, pregnancy and birth conditions were extracted as potential confounders. Adult health behaviors, BMI, socioeconomic environment and psychological state were considered as mediating variables. Multivariate models were performed by including variables sequentially taking a lifecourse approach. Results: 37.5 % of men and 19.8 % of women had MetS. Participants with an obese/overweight mother presented a higher risk of MetS than those whose mother had a normal pre-pregnancy BMI. Men exposed to two ACE or more, and women exposed to one ACE, were more at risk of MetS compared to unexposed individuals. After including confounders and mediators, mother’s pre-pregnancy BMI was still associated with MetS in midlife but the association was weakened after including participant’s adult BMI. ACE was no longer associated with MetS after including confounders in models. Conclusions: The early nutritional environment, represented by mother’s pre-pregnancy BMI, was associated with the risk of MetS in midlife. An important mechanism involves a mother-to-child BMI transmission, independent of birth or perinatal conditions, socioeconomic characteristics and health behaviors over the lifecourse. However this mechanism is not sufficient for explaining the influence of mother’s pre-pregnancy BMI which implies the need to further explore other mechanisms in particular the role of genetics and early nutritional environment. ACE is not independently associated with MetS. However, other early life stressful events such as emergency caesarean deliveries and poor socioeconomic status during childhood may contribute as determinants of MetS.
dc.description.sponsorshipEnvironnement psychosocial précoce, empreintes biologiques et épigénétiques et état de santé à l'âge adulte - ANR-12-DSSA-0004en_US
dc.language.isoENen_US
dc.rightsAttribution 3.0 United States*
dc.rights.urihttp://creativecommons.org/licenses/by/3.0/us/*
dc.subject.enMetabolic syndrome
dc.subject.enEarly nutritional exposure
dc.subject.enEarly psychosocial exposures
dc.subject.enCohort studies
dc.subject.enSocial epidemiology
dc.subject.enLifecourse
dc.title.enThe early life nutritional environment and early life stress as potential pathways towards the metabolic syndrome in mid-life? A lifecourse analysis using the 1958 British Birth cohort
dc.typeArticle de revueen_US
dc.identifier.doi10.1186/s12889-016-3484-0en_US
dc.subject.halSciences du Vivant [q-bio]/Neurosciences [q-bio.NC]en_US
dc.identifier.pubmed27538482en_US
bordeaux.journalBMC Public Healthen_US
bordeaux.page815en_US
bordeaux.volume16en_US
bordeaux.hal.laboratoriesNutriNeurO (Laboratoire de Nutrition et Neurobiologie Intégrée) - UMR 1286en_US
bordeaux.issue1en_US
bordeaux.institutionUniversité de Bordeauxen_US
bordeaux.institutionINRAEen_US
bordeaux.peerReviewedouien_US
bordeaux.inpressnonen_US
bordeaux.identifier.funderIDAgence Nationale de la Rechercheen_US
hal.exportfalse
workflow.import.sourcepubmed
dc.rights.ccCC BYen_US
bordeaux.COinSctx_ver=Z39.88-2004&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.jtitle=BMC%20Public%20Health&rft.date=2016-08-18&rft.volume=16&rft.issue=1&rft.spage=815&rft.epage=815&rft.eissn=1471-2458&rft.issn=1471-2458&rft.au=DELPIERRE,%20Cyrille&FANTIN,%20Romain&BARBOZA-SOLIS,%20Christina&LEPAGE,%20Benoit&DARNAUDERY,%20Muriel&rft.genre=article


Archivos en el ítem

Thumbnail
Thumbnail

Este ítem aparece en la(s) siguiente(s) colección(ones)

Mostrar el registro sencillo del ítem